Results 11 to 20 of about 802,092 (249)

Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats [PDF]

International Journal of Ophthalmology, 2015
AIM:To investigate the effect of emodin on pseudomonas aeruginosa lipopolysaccharides (LPS)-induced corneal inflammation in rats.METHODS:Corneal infection was induced by pseudomonas aeruginosa LPS in Wistar rats.
Guo-Ling Chen, Jing-Jing Zhang, Xin Kao, Lu-Wan Wei, Zhi-Yu Liu   +4 more
doaj   +2 more sources

The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor

Drug Design, Development and Therapy, 2018
Ling Chen,* Jing Zhong,* Saiqun Li, Weihua Li, Bowen Wang, Yuqing Deng, Jin Yuan State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China *These authors contributed equally to this work ...
Chen L, Zhong J, Li S, Li W, Wang B, Deng Y, Yuan J   +6 more
doaj   +1 more source

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis [PDF]

, 2011
Background: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6(+/-) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal ...
Fullwood, Nigel J., Martin, Francis L., Collinson, J. Martin, Richard L Mort, Morley, Steven D., Morley Steven D., West John D., Bentley, Adam J., Adam J Bentley, Mort, Richard L, Collinson J. Martin, Panagiotis Douvaras, Collinson, J Martin, J Martin Collinson, Bentley Adam J., Mort Richard L., Martin, Francis L, Bentley, Adam J, Morley, Steven D, Martin Francis L., Douvaras, Panagiotis, Steven D Morley, Robert E Hill, Mort, Richard L., West, John D., Hill, Robert E, Fullwood, Nigel J, Nigel J Fullwood, Douvaras Panagiotis, Fullwood Nigel J., Francis L Martin, Hill Robert E., Hill, Robert E., West, John D, John D West   +34 more
core   +5 more sources

Unilateral Corneal Insult Also Alters Sensory Nerve Activity in the Contralateral Eye

Frontiers in Medicine, 2021
After the unilateral inflammation or nerve lesion of the ocular surface, the ipsilateral corneal sensory nerve activity is activated and sensitized, evoking ocular discomfort, irritation, and pain referred to the affected eye.
Carolina Luna, Susana Quirce, Adolfo Aracil-Marco, Carlos Belmonte, Juana Gallar, Juana Gallar, M. Carmen Acosta   +6 more
doaj   +1 more source

Fulminant Marginal Keratitis Induced by Atezolizumab, a Programmed Death Ligand 1 Inhibitor for Lung Cancer

Case Reports in Ophthalmology, 2023
Introduction: With the increasing use of immune checkpoint inhibitors, ocular adverse events have gained attention. We describe a case of atypical keratitis presumably induced by atezolizumab, a programmed cell death ligand 1 inhibitor. Case Presentation:
Masashi Yamamoto, Masakazu Yamada, Yumi Kusumi, Masaki Fukui, Chika Shigeyasu   +4 more
doaj   +1 more source

Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases

Cells, 2022
Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro   +6 more
doaj   +1 more source

PAC1 receptor agonist maxadilan alleviates corneal inflammation in a murine model of LPS-induced ocular inflammation. [PDF]

PLoS One
Ocular inflammation is a leading cause of visual impairment and blindness worldwide. Systemic bacterial infections can spread hematogenously, resulting in endogenous endophthalmitis.
Dobos A, Meresz B, Bosnyak I, Molitor D, Kocsis B, Szabo E, Reglodi D, Vajda I, Atlasz T, Vaczy A.   +9 more
europepmc   +2 more sources

Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. [PDF]

PLoS ONE, 2013
Inflammation and angiogenesis are integral parts of wound healing. However, excessive and persistent wound-induced inflammation and angiogenesis in an avascular tissue such as the cornea may be associated with scarring and visual impairment.
Sharmila Chatterjee, Yan Wang, Melinda K Duncan, Ulhas P Naik   +3 more
doaj   +1 more source

CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue

Antioxidants, 2021
Cytotoxic T lymphocyte antigen-2 (CTLA-2) alpha has been reported to suppress the activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue.
Kazuichi Maruyama, Kazuhito Yoneda, Sunao Sugita, Yoshimi Yamamoto, Masato Koike, Christoph Peters, Yasuo Uchiyama, Kohji Nishida   +7 more
doaj   +1 more source

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +1 more source