Results 21 to 30 of about 147,554 (211)

Mechanical Properties of Bioengineered Corneal Stroma. [PDF]

Adv Healthc Mater, 2021
Abstract For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal ...
Formisano N, van der Putten C, Grant R, Sahin G, Truckenmüller RK, Bouten CVC, Kurniawan NA, Giselbrecht S.   +7 more
europepmc   +6 more sources

Evolution of the vertebrate corneal stroma [PDF]

Progress in Retinal and Eye Research, 2018
Although the cornea is the major refractive element of the eye, the mechanisms controlling corneal shape and hence visual acuity remain unknown. To begin to address this question we have used multiphoton, non-linear optical microscopy to image second harmonic generated signals (SHG) from collagen to characterize the evolutionary and structural changes ...
Elena Koudouna, Moritz Winkler, Eric Mikula, Tibor Juhasz, Donald J. Brown, James V. Jester   +5 more
openaire   +2 more sources

Protection effect of thymosin β4 on ethanol injury in corneal stromal keratocyte

BMC Ophthalmology, 2022
Purpose To investigate the protective effects of thymosin β4 (Tβ4) on ethanol injured human corneal keratocytes (HCKs). Methods HCKs and BALB/c mice were chosen as the study subject. Ethanol was used to treat the cells and corneal stroma of mice to build
Jinghua Liu, Chen Guo, Peng Hao, Peihong Wang, Linghan Li, Yuchuan Wang, Xuan Li   +6 more
doaj   +1 more source

Composition, structure and function of the corneal stroma. [PDF]

Exp Eye Res, 2020
No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent ...
Espana EM, Birk DE.
europepmc   +4 more sources

The Yin and Yang of Mesenchymal Cells in the Corneal Stromal Fibrosis Response to Injury: The Cornea as a Model of Fibrosis in Other Organs

Biomolecules, 2022
Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors to stromal fibrosis after injury to the cornea.
Steven E. Wilson
doaj   +1 more source

A study of visual outcome in deep anterior lamellar keratoplasty at a tertiary eye care institute

Indian Journal of Transplantation, 2022
Introduction: Deep anterior lamellar keratoplasty is a surgical procedure for removing the corneal stroma down to Descemet's membrane. It is most useful for the treatment of corneal disease in the setting of a normally functioning endothelium.
Superna Mahendra, Srinivas Prasad Killani, Swathi Pola   +2 more
doaj   +1 more source

Stromal Collagen Arrangement Correlates with Stiffness of the Canine Cornea

Bioengineering, 2019
The cornea is the most external layer of the eye and serves two important roles in (1) the refraction of light and (2) protection from the outside environment, both of which are highly dependent on the collagen assembly of the corneal stroma.
Brian C. Leonard, Krista Cosert, Moritz Winkler, Ariana Marangakis, Sara M. Thomasy, Christopher J. Murphy, James V. Jester, Vijay Krishna Raghunathan   +7 more
doaj   +1 more source

Changes of matrix metalloproteinases in the stroma after corneal cross-linking in rabbits [PDF]

International Journal of Ophthalmology, 2021
AIM: To observe changes in the content of matrix metalloproteinases (MMPs) in the corneal stroma after corneal cross-linking (CXL) in rabbits, and further explore the corneal pathophysiological process after CXL. METHODS: Forty-two rabbits (42 eyes) were
Hong-Zhen Jia, Xu Pang, Xiu-Jun Peng
doaj   +1 more source

Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model

Stem Cell Research & Therapy, 2017
Background We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane.
Jialin Chen, Wei Zhang, Peyman Kelk, Ludvig J. Backman, Patrik Danielson   +4 more
doaj   +1 more source

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Phipps, Richard P., Holly B Hindman, MacRae, Scott, Patricia J Sime, Krystel R Huxlin, David Ciufo, Jeon, Kye-Im, Richard P Phipps, Sime, Patricia J., DeMagistris, Margaret, Ciufo, David, Huxlin, Krystel R., Jens Bühren, Scott MacRae, Kye-Im Jeon, Margaret DeMagistris, Bühren, Jens, Hindman, Holly B., DeMagistris Margaret, Sime Patricia J., Phipps Richard P., Huxlin Krystel R., MacRae Scott, Hindman Holly B., Bühren Jens, Jeon Kye-Im, Ciufo David   +26 more
core   +2 more sources