Results 91 to 100 of about 981,607 (247)

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Salient features of the coronary collateral circulation and its clinical relevance

Swiss Medical Weekly, 2015
The coronary collateral circulation provides an alternative source of blood supply to myocardium jeopardised by ischaemia. Collaterals enlarge with obstructive coronary artery disease to allow bulk flow, but blood flow deliverable by the native, pre ...
Michael Stoller, Christian Seiler
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Relation between Preinfarction Angina and Coronary Collateral Circulation in Patients with Acute Myocardial Infarction

Althea Medical Journal, 2016
Background: Coronary collateral circulation conduits an alternative blood flow to the ischemic myocardium in the setting of coronary artery occlusion which can prevent the infarction area to extend more widely.
Achmad Shidiq, Syarief Hidayat, Januarsih Iwan Rachman   +2 more
doaj   +1 more source

THE CORONARY CIRCULATION

Physiological Reviews, 1946
O D, RATNOFF, M, PLOTZ
openaire   +5 more sources

Percutaneous coronary intervention in the elderly: changes in case-mix and periprocedural outcomes in 31758 patients treated between 2000 and 2007 [PDF]

, 2010
<p>Background: The elderly account for an increasing proportion of the population and have a high prevalence of coronary heart disease. Percutaneous coronary intervention (PCI) is the most common method of revascularization in the elderly.
Pell, A.C.H., Oldroyd, K.G., Flapan, A.D., Cathy Johnman, Pell, J.P., Mackay, D.F., Kevin P. Jennings, Jennings, K.P., Alastair C.H. Pell, Keith G. Oldroyd, Danny F. Mackay, Rachel Slack, John Irving, Slack, R., Eteiba, H., Irving, J., Jill P. Pell, Andrew D. Flapan, Johnman, C., Hany Eteiba   +19 more
core   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery [PDF]

, 2009
: Objective To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery.
Hemingway, Harry,, Hemingway, Harry, Sculpher, Mark,, Timmis, Adam,, Sculpher, Mark, Abrams, Keith,, Henriksson, M, K Fitzpatrick, Natalie,, Hingorani, Aroon D,, Chen, R, Kaski, Juan-Carlos,, Stenestrand, Ulf, Stenestrand, Ulf,, Hingorani, AD, Feder, G, Henriksson, Martin,, Janzon, M, Janzon, Magnus, Fitzpatrick, NK, Abrams, K, Damant, Jacqueline, Feder, Gene,, Palmer, S, Damant, Jacqueline,, Shipley, MJ, Chen, Ruoling, Timmis, A, K Fitzpatrick, Natalie, Abrams, Keith, Sculpher, M, Palmer, Stephen, Stenestrand, U, Keogh, B, Janzon, Magnus,, Damant, J, Feder, Gene, Shipley, Martin J, Henriksson, Martin, Kaski, JC, Hingorani, Aroon D, Keogh, Bruce, Keogh, Bruce,, Hemingway, H, Timmis, Adam, Fitzpatrick, Natalie K, Shipley, Martin J,, Kaski, Juan-Carlos   +46 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source