Results 61 to 70 of about 13,767 (259)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

HDL-C and systemic inflammatory response index mediate the association between visceral adipose tissue and risk of cardiovascular disease among young and middle-aged adults with prediabetes or diabetes: a national cohort study

Journal of Translational Medicine
Background Visceral adipose tissue (VAT) is a harmful fat linked to cardiovasular disease (CVD). This study aims to investigate the relationship between VAT, as measured by dual-energy X-ray absorptiometry, and CVD risk in young and middle-aged adults ...
Wanzhou Wu, Feng Zhang, Song Wen, Xueting Qiu   +3 more
doaj   +1 more source

Coronary Stenting in 15 Year-old Boy with Coronary Artery Stenosis Secondary to Kawasaki Disease [PDF]

, 2000
Kawasaki disease is an acute febrile illness frequently developed in infants and children. This disease may involve coronary arteries in 15-25% of the patients and may progress to coronary aneurysms, ischemic cardiac diseases, and sudden cardiac death ...
고영국
core  

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Hyperinsulinemia and Poor Coronary Collateral Circulation in Coronary Artery Occlusion: A Novel Finding, Yet of Therapeutic Significance or Not [Letter]

Diabetes, Metabolic Syndrome and Obesity, 2023
Mahnoor Asif,* Syeda Sakina Zehra,* Tanzila Siddiqui Karachi Medical and Dental College, Karachi, Pakistan*These authors contributed equally to this workCorrespondence: Syeda Sakina Zehra, Tel +92 3322609216, Email szehra362@gmail ...
Asif M, Zehra SS, Siddiqui T
doaj  

Morphometric Reconstruction of Coronary Vasculature Incorporating Uniformity of Flow Dispersion

Frontiers in Physiology, 2018
Experimental limitations in measurements of coronary flow in the beating heart have led to the development of in silico models of reconstructed coronary trees.
Ravi Namani, Ravi Namani, Ghassan S. Kassab, Yoram Lanir   +3 more
doaj   +1 more source

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. [PDF]

, 2011
The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be
Hilma Holm, Poschen Ulrike, Panos Deloukas, Assimes, Themistocles L., Karakas, Mahir, Mahir Karakas, Erdmann, Jeanette, Moll, F.L., Robert Roberts, Illig, T., Samani, Nilesh J, Sekar Kathiresan, Muredach P Reilly, Koenig Wolfgang, Dominique P. V. de Kleijn, Herder, C., Thorand, Barbara, Illig Thomas, Preuss Michael, Pasterkamp, Gerard, Moll Frans L., null null, Ruth McPherson, König, Inke R, Poschen, Ulrike, Samani, Nilesh J., Karakas, M., Thorgeirsson, Gudmundur, de Kleijn Dominique P. V., Preuss, M, Frans L Moll, Alexandre F R Stewart, Meisinger Christa, Koenig, W., Holm, Hilma, de Kleijn, Dominique P. V., CARDIoGRAM Consortium, König, Inke R., Ulrike Poschen, Moll, Frans L, Roberts, Robert, Peeters, Wouter, Koenig, Wolfgang, Karakas Mahir, Müller-Nurasyid, Martina, Jeanette Erdmann, Wouter Peeters, Thorand Barbara, Meisinger, Christa, Herder Christian, Klopp, Norman, Roden, M., Herder, Christian, Moll, Frans L., Roden, Michael, Stewart, Alexandre FR, Gerard Pasterkamp, Heribert Schunkert, Martina Müller-Nurasyid, Müller-Nurasyid, M., Pasterkamp Gerard, Jens Baumert, Roden Michael, Klopp, N., McPherson, Ruth, Reilly, Muredach P, Inke R König, Deloukas, Panos, Schunkert, Heribert, Dominique P V de Kleijn, Kathiresan, Sekar, Wolfgang Koenig, Barbara Thorand, CARDIoGRAM Consortium (Illig, T. ; Wichmann, H.-E. ; Döring, A. ; Peters, A. ; Meitinger, T. ; Klopp, N. ; Meisinger, C.), Müller-Nurasyid Martina, Michael Preuss, Poschen, U., Preuss, Michael, Peeters, W., Illig, Thomas, Baumert, Jens, Reilly, Muredach P., Frans L. Moll, Christian Herder, Thomas Illig, Christa Meisinger, Stewart, Alexandre F. R., Klopp Norman, Meisinger, C., Assimes, Themistocles L, Peeters Wouter, de Kleijn, Dominique PV, Baumert Jens, de Kleijn, D.P., Stewart, Alexandre F R, de Kleijn, Dominique P V, Michael Roden, Themistocles L Assimes, Nilesh J Samani, Norman Klopp, Baumert, J.J., Thorand, B., Pasterkamp, G.   +102 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease

American Journal of Preventive Cardiology
Objective: To evaluate whether and to what extent changes in cardiovascular health (CVH) based on life's essential 8 (LE8) are associated with incident cardiovascular disease (CVD). Methods: A total of 7,194 participants were derived from UK Biobank. CVH
Chao Song, Xunjie Cheng, Yongping Bai
doaj   +1 more source