Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang+3 more
wiley +1 more source
Cost-effectiveness of low-dose colchicine in patients with chronic coronary disease in The Netherlands. [PDF]
Fiolet ATL+13 more
europepmc +1 more source
A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao+7 more
wiley +2 more sources
Associations between depression, resilience, and fatigue in patients with multivessel coronary disease: A cross-lag study. [PDF]
Sun B+5 more
europepmc +1 more source
The etiology of cardiac enlargement in coronary occlusion, hypertension, and coronary artery disease
Arthur M. Mastér
openalex +1 more source
Cystatin C as Biomarker for the Evaluation of Renal Outcome in AL Amyloidosis
ABSTRACT Cystatin C (CysC) has emerged as a novel and potentially more reliable biomarker for the estimation of glomerular filtration in the general population in patients with various conditions. In AL amyloidosis, the current renal staging system and renal response criteria are based on proteinuria and creatinine‐based eGFR.
Foteini Theodorakakou+18 more
wiley +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker+3 more
wiley +2 more sources
In-stent neoatherosclerosis: a new problem or an opportunity to rethink the treatment of coronary disease? [PDF]
Ussia GP, Cocco N.
europepmc +1 more source
Simplified Approach to Predicting Obstructive Coronary Disease With Integration of Coronary Calcium: Development and External Validation. [PDF]
Miller RJH+11 more
europepmc +1 more source