Results 211 to 220 of about 1,293,045 (377)

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang   +3 more
wiley   +1 more source

Cost-effectiveness of low-dose colchicine in patients with chronic coronary disease in The Netherlands. [PDF]

open access: yesEur Heart J Qual Care Clin Outcomes
Fiolet ATL   +13 more
europepmc   +1 more source

Spatiotemporal Super‐Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions

open access: yesAngewandte Chemie, EarlyView.
A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao   +7 more
wiley   +2 more sources

Cystatin C as Biomarker for the Evaluation of Renal Outcome in AL Amyloidosis

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Cystatin C (CysC) has emerged as a novel and potentially more reliable biomarker for the estimation of glomerular filtration in the general population in patients with various conditions. In AL amyloidosis, the current renal staging system and renal response criteria are based on proteinuria and creatinine‐based eGFR.
Foteini Theodorakakou   +18 more
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

open access: yesAngewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker   +3 more
wiley   +2 more sources

Simplified Approach to Predicting Obstructive Coronary Disease With Integration of Coronary Calcium: Development and External Validation. [PDF]

open access: yesJ Am Heart Assoc, 2023
Miller RJH   +11 more
europepmc   +1 more source

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