Results 101 to 110 of about 455,893 (183)

PRotective Effect on the coronary microcirculation of patients with DIabetes by Clopidogrel or Ticagrelor (PREDICT): study rationale and design. A randomized multicenter clinical trial using intracoronary multimodal physiology

Cardiovascular Diabetology, 2017
Background In diabetic patients a predisposed coronary microcirculation along with a higher risk of distal particulate embolization during primary percutaneous intervention (PCI) increases the risk of peri-procedural microcirculatory damage. However, new
Enrico Cerrato, Alicia Quirós, Mauro Echavarría-Pinto, Hernan Mejia-Renteria, Andres Aldazabal, Nicola Ryan, Nieves Gonzalo, Pilar Jimenez-Quevedo, Luis Nombela-Franco, Pablo Salinas, Iván J. Núñez-Gil, José Ramón Rumoroso, Antonio Fernández-Ortiz, Carlos Macaya, Javier Escaned   +14 more
doaj   +1 more source

15O‐water PET‐detected myocardial ischaemia and CT‐derived FFR: Predicting the functional significance of anatomical stenosis

Clinical Physiology and Functional Imaging, Volume 46, Issue 6, November 2026.
Abstract Aims Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. While coronary computed tomography angiography (CCTA) provides anatomical assessment of coronary stenoses, its ability to determine their functional significance is limited. Computed tomography‐derived fractional flow reserve (CT‐FFR) has emerged as a non‐
Vornanen J, Okkonen M, Ronkainen A‐P, Laitinen Tm, Laitinen Tp, Hedman M   +5 more
wiley   +1 more source

Intracoronary Delivery of Human Mesenchymal/Stromal Stem Cells: Insights from Coronary Microcirculation Invasive Assessment in a Swine Model. [PDF]

, 2015
Mesenchymal stem/stromal cells have unique properties favorable to their use in clinical practice and have been studied for cardiac repair. However, these cells are larger than coronary microvessels and there is controversy about the risk of embolization
António Fiarresga, Belmira Carrapiço, Selas, M, Cardim, Nuno, Oliveira, Eunice, Cavaco-Gonçalves, Sandra, Eunice Oliveira, Mata, M, Rui Cruz Ferreira, Márcia F. Mata (815500), Irina N. Simões (815503), Selas, Mafalda, da Silva, Cláudia Lobato, Cavaco-Gonçalves, S, Cabral, J, Oliveira, E, Sandra Cavaco-Gonçalves (815501), Nuno Cardim (815506), Joaquim M S Cabral, António Fiarresga (815499), Cardim, N, Carrapiço, Belmira, Cruz Ferreira, R, Sandra Cavaco-Gonçalves, Eunice Oliveira (815504), Simões, I, Fiarresga, António, Silva, C, Mata, Márcia F., Rui Cruz Ferreira (815507), Simões, Irina N., Joaquim M. S. Cabral (141046), Márcia F Mata, Cruz Ferreira, Rui, Cláudia L. da Silva (141035), Cláudia L da Silva, Irina N Simões, Fiarresga, A, Belmira Carrapiço (815505), Cabral, Joaquim M. Sampaio, Carrapiço, B, Nuno Cardim, Mafalda Selas (815502), Mafalda Selas, Cabral Joaquim M. S., Simões Irina N., Cavaco-Gonçalves Sandra, da Silva Cláudia L., Selas Mafalda, Mata Márcia F., Ferreira Rui Cruz, Cardim Nuno, Oliveira Eunice, Carrapiço Belmira, Fiarresga António   +54 more
core   +1 more source

Association of Lipid Ratios With Cardiovascular Outcomes in Type 2 Diabetes: A Population Cohort Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10236-10247, November 2026.
ABSTRACT Aims To identify low‐ and high‐risk intervals for major adverse cardiovascular events (MACE) and all‐cause mortality according to lipid ratios in adults with Type 2 diabetes mellitus (T2DM), stratified by sex. Materials and Methods We used primary care electronic health records from the Spanish National Health Service including 303 199 adults ...
Enrique Carretero‐Anibarro, Jose Antonio Quesada, Manuel A. Ruiz‐Quintero, Didac Mauricio, Kamlesh Khunti, Domingo Orozco‐Beltrán   +5 more
wiley   +1 more source

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard, Eichhorn, M. E.;Ney, L.;Massberg, S.;Goetz, A. E.   +4 more
core   +1 more source

Influence of age on the development of stress hyperglycemia during first‐onset ST‐elevation myocardial infarction

Journal of Diabetes Investigation, Volume 17, Issue 11, Page 1997-2008, November 2026.
Among 8,779 non‐diabetic patients with first‐onset STEMI, older age was associated with a higher likelihood of stress hyperglycemia. However, the excess mortality risk associated with stress hyperglycemia was greatest in younger patients and attenuated with advancing age, highlighting the possibility of age‐dependent prognostic significance.
Hon Jen Wong, Joy Xin Yi Au, Yao Hao Teo, Yao Neng Teo, Chen Ee Low, Chun En Yau, Norman H.Y. Lin, Pei Chia Eng, Li Feng Tan, Reshma A. Merchant, Ping Chai, Anand Adinath Ambhore, James W. L. Yip, Andrew Fu‐Wah Ho, David Foo, Pow‐Li Chia, Patrick Zhan‐Yun Lim, Khung Keong Yeo, Weien Chow, Daniel Thuan Tee Chong, Derek J. Hausenloy, Mark Y. Y. Chan, Ching‐Hui Sia   +22 more
wiley   +1 more source

Coronary Flow Reserve in Adults: Pathophysiology, Assessment Modalities, Clinical Applications, and Prognostic Significance

Medicina
Coronary flow reserve (CFR) is a fundamental physiological index defined as the ratio of maximal coronary blood flow during hyperemia to resting flow. It provides an integrated assessment of the entire coronary circulation, from epicardial arteries to ...
Konstantinos Katogiannis, Jimmy T. Efird, Artur Dziewierz, Francisco Epelde, Ignatios Ikonomidis   +4 more
doaj   +1 more source

Dynamic Changes in Microvascular Flow Conductivity and Perfusion After Myocardial Infarction Shown by Image‐Based Modeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Microcirculation is a decisive factor in tissue reperfusion inadequacy following myocardial infarction (MI). Nonetheless, experimental assessment of blood flow in microcirculation remains a bottleneck.
Polyxeni Gkontra, Wahbi K. El‐Bouri, Kerri‐Ann Norton, Andrés Santos, Aleksander S. Popel, Stephen J. Payne, Alicia G. Arroyo   +6 more
doaj   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, Volume 111, Issue 11, Page 4979-4986, 1 November 2026.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Assessment of coronary microcirculation in a swine animal model

, 2011
Coronary microvascular dysfunction has important prognostic implications. Several hemodynamic indexes, such as coronary flow reserve (CFR), microvascular resistance, and zero-flow pressure (Pzf), were used to establish the most reliable index to assess ...
Shigeho Takarada, Zhang Zhang, Sabee Molloi   +2 more
core   +1 more source