Results 91 to 100 of about 455,893 (183)

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

The Coronary Microcirculation Re-explored:Pathophysiological Insights and Clinical Implications [PDF]

Coronary microvascular dysfunction (CMD) is being increasingly recognised as a significant contributor to myocardial ischaemia, particularly in patients without obstructive coronary artery disease.
Abdimalik, Mustafa, Abo Al Hayja, Muntasir, Lip, Gregory Yh, Abdelrahim, Mohanad, Giblett, Joel, Fisher, Michael, Elamin, Ahmed, Fairbairn, Tim, Al Hayja, Muntasir Abo   +8 more
core   +1 more source

Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction?

Biomedicines
The understanding of coronary artery disease is evolving, with more attention given currently to the microcirculation compartment. Coronary microvascular dysfunction (CMD) is defined by any structural or functional alteration of the coronary ...
Georgiana Pintea Bentea, Ahmad Awada, Brahim Berdaoui   +2 more
doaj   +1 more source

Physiology of Coronary Microcirculation

, 2022
info:eu-repo/semantics ...
Jacinto, S, Morais, L
openaire   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2378-2389, November 2026.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Exercise‐Based Management of Diabetic Cardiomyopathy: Preclinical Mechanisms, Clinical Evidence, and Translational Strategies

Journal of Diabetes, Volume 18, Issue 11, November 2026.
Exercise may mitigate diabetic cardiomyopathy by improving mitochondrial metabolism, redox balance, calcium handling, and inflammatory‐fibrotic remodeling. Translation into clinical practice requires phenotype‐ and risk‐adapted exercise prescriptions, standardized dose reporting, and multimodal monitoring to define safety, efficacy, and long‐term ...
Xiaoya Li, Zhiqiang Wang, Jingjing Liu
wiley   +1 more source

Central and Peripheral Circulation Differ during Off-Pump Coronary Artery Bypass Grafting

Reviews in Cardiovascular Medicine
Background: Off-pump coronary artery bypass grafting (OPCAB) is an alternative to on-pump coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB).
Lars Saemann, Alina Zubarevich, Folker Wenzel, Jasmin Soethoff, Sevil Korkmaz-Icöz, Fabio Hoorn, Matthias Karck, Andreas Simm, Gábor Szabó, Gábor Veres   +9 more
doaj   +1 more source

Diffusely impaired myocardial perfusion in patients with suspected coronary artery disease: Clinical utility of relative perfusion

Clinical Physiology and Functional Imaging, Volume 46, Issue 6, November 2026.
Abstract Background In patients with suspected coronary artery disease (CAD), diffusely impaired hyperaemic myocardial blood flow (MBF) may indicate a multivessel epicardial CAD but also impaired coronary microcirculation. We assessed whether relative hyperaemic MBF—that is, the ratio of the lowest to the highest regional hyperaemic MBF—predicts ...
Niklas Vartiainen, Antti‐Pekka E. Rissanen, Suvi Hartikainen, Svantte Halttunen, Aleksi J. Leikas, Elina Kariniemi, Eero Strengell, Paavo‐Ilari Kuikka, Juha E. K. Hartikainen, Tomi P. Laitinen   +9 more
wiley   +1 more source

Stimulated leukocyte adhesion in coronary microcirculation is reduced by a calcium antagonist

, 1993
The first step in the acute myocardial inflammatory response is leukocyte sequestration in the coronary microcirculation. To determine the location(s) of stimulated leukocyte deposition in the coronary microcirculation and the effects of the calcium ...
M. J. Rauzzino, P. F. McDonagh
core   +1 more source

Image deblurring for visualization of coronary microcirculation [PDF]

, 1991
Blurred images of the rat coronary microcirculation have been obtained and processed. Heart motion, blood flow and noise cause the blur of the images. The objective of this thesis work was to study the effects of these factors on image quality and assess
Wang, Kaijun
core   +1 more source