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Molecular Mechanisms of Endothelial Dysfunction in Coronary Microcirculation Dysfunction
Journal of Thrombosis and Thrombolysis, 2023Coronary microvascular endothelial cells (CMECs) react to changes in coronary blood flow and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors-such as endothelin-1-and the vessel dilators prostaglandin, nitric oxide, and endothelium-dependent hyperpolarizing factor. Coronary microvascular endothelial cell dysfunction
Jing-Yue Wang, Jiahuan He
exaly +3 more sources
European Journal of Ophthalmology, 2022
Purpose The aim of this study is to evaluate the correlation between retinopathy and coronary microcirculation dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients. Methods 198 T2DM patients with left ventricular ejection ...
Weihua Wu, Qian Wang, Ziying Zhang
exaly +3 more sources
Purpose The aim of this study is to evaluate the correlation between retinopathy and coronary microcirculation dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients. Methods 198 T2DM patients with left ventricular ejection ...
Weihua Wu, Qian Wang, Ziying Zhang
exaly +3 more sources
Lancet, The, 1991
Hypercholesterolaemia impairs endothelial function, possibly by interference with the intracellular formation of endothelium-derived relaxing factor from its precursor L-arginine. Whether L-arginine reverses hypercholesterolaemia-induced endothelial dysfunction in the coronary circulation was thus investigated.
A M Zeiher, H Drexler, H Just
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Hypercholesterolaemia impairs endothelial function, possibly by interference with the intracellular formation of endothelium-derived relaxing factor from its precursor L-arginine. Whether L-arginine reverses hypercholesterolaemia-induced endothelial dysfunction in the coronary circulation was thus investigated.
A M Zeiher, H Drexler, H Just
exaly +3 more sources
International Journal of Cardiology, 2016
To determine whether tirofiban can prevent microcirculation dysfunction during delayed percutaneous coronary intervention (PCI) of spontaneously recanalized and severe narrowing coronary artery in patients with acute myocardial infarction.62 patients who have a single angiographically confirmed narrowing culprit coronary artery for more than 75 ...
Jianping Zeng
exaly +3 more sources
To determine whether tirofiban can prevent microcirculation dysfunction during delayed percutaneous coronary intervention (PCI) of spontaneously recanalized and severe narrowing coronary artery in patients with acute myocardial infarction.62 patients who have a single angiographically confirmed narrowing culprit coronary artery for more than 75 ...
Jianping Zeng
exaly +3 more sources
Coronary Microvascular Dysfunction
Journal of Clinical Medicine, 2020 Many patients with chest pain undergoing coronary angiography do not show significant obstructive coronary lesions. A substantial proportion of these patients have abnormalities in the function and structure of coronary microcirculation due to ...
Federico Vancheri, Sérgio Vancheri
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The coronary microcirculation and coronary microvascular dysfunction
2021The role of revascularization in the treatment of obstructive coronary artery disease is well established, and its impact on improving survival has been proven. Nevertheless, patients with signs and symptoms considered of cardiac origin but with no obstructive coronary artery disease on coronary angiography are increasingly seen. Initially described as
Romana Herscovici, C. Noel Bairey Merz
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Atherosclerosis, 2023 : Although atherosclerosis is usually considered a disease of the large arteries, risk factors for atherosclerosis also trigger structural and functional abnormalities at a microvascular level.
Peter L M Kerkhof, Roberta Montisci
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[Advancement of imaging technology for coronary microcirculation dysfunction assessment].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2021Coronary microcirculation dysfunction (CMVD) is an important risk factor for the prognosis of re-perfused ischemic heart. Recent studies showed that the evaluation of CMVD has significant impact on both the early diagnosis of heart diseases relevant to blood supply and prognosis after myocardial reperfusion.
Bowei, Liu +6 more
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