Results 1 to 10 of about 1,148,220 (337)

Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021

Bulletin of the National Research Centre, 2021
Background Indonesia has started the big project of COVID-19 vaccination program since 13 January 2021 by employing the first shot of vaccine to the President of Indonesia as the outbreak and rapid transmission of COVID-19 have endangered not only ...
Reviany V. Nidom, Setyarina Indrasari, Irine Normalina, Astria N. Nidom, Balqis Afifah, Lestari Dewi, Andra K. Putra, Arif N. M. Ansori, Muhammad K. J. Kusala, Mohammad Y. Alamudi, Chairul A. Nidom   +10 more
doaj   +1 more source

Delayed RT-PCR Time-To-Positivity in an adult with SARS-CoV-2 Infection

Journal of Infection in Developing Countries, 2021
Early diagnosis is among the crucial measures to control the spread of SARS-CoV-2 infection. To date, reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for COVID-19 testing, but various factors can affect its performance ...
Nur Chandra Bunawan, Md Ikhsan Mokoagow, Aryan Yohanes Djojo, Natalia Wistriany, Hardijatmo Muljo Nugroho, Annisa Dian Harlivasari, Setioningsih Diponegoro   +6 more
doaj   +1 more source

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

Nature Communications, 2022
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domain as ...
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan   +13 more
doaj   +1 more source

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

eLife, 2023
SARS-CoV-2 spike protein plays a key role in mediating viral entry and inducing host immune responses. It can adopt either an open or closed conformation based on the position of its receptor-binding domain (RBD).
Qibin Geng, Yushun Wan, Fu-Chun Hsueh, Jian Shang, Gang Ye, Fan Bu, Morgan Herbst, Rowan Wilkens, Bin Liu, Fang Li   +9 more
doaj   +1 more source

The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes

Scientific Reports, 2021
The COVID-19 pandemic has affected more than 100 million cases and caused immense burdens on governments and healthcare systems worldwide. Since its emergence in December 2019, research has been focused on treating the infected, identifying those at risk
Marwa Ali Almadhi, Abdulkarim Abdulrahman, Abdulla Alawadhi, Ali A. Rabaan, Stephen Atkin, Manaf AlQahtani   +5 more
doaj   +1 more source

Evaluation of Rapid Antigen Tests Using Nasal Samples to Diagnose SARS-CoV-2 in Symptomatic Patients

Frontiers in Public Health, 2022
IntroductionThe best way to mitigate an outbreak besides mass vaccination is via early detection and isolation of infected cases. As such, a rapid, cost-effective test for the early detection of COVID-19 is required.MethodsThe study included 4,183 mildly
Manaf Alqahtani, Manaf Alqahtani, Manaf Alqahtani, Abdulkarim Abdulrahman, Abdulkarim Abdulrahman, Fathi Mustafa, Fathi Mustafa, Abdulla I. Alawadhi, Abdulla I. Alawadhi, Batool Alalawi, Saad I. Mallah   +10 more
doaj   +1 more source

COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study

BMC Infectious Diseases, 2021
Background Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases.
Abdulkarim Abdulrahman, Saad I. Mallah, Manaf Alqahtani   +2 more
doaj   +1 more source

A case study of a community-organized wastewater surveillance in a small community: correlating weekly reported COVID-19 cases with SARS-CoV-2 RNA concentrations during fall 2020 to summer 2021 in Yarmouth, ME

Journal of Water and Health, 2023
Wastewater surveillance offers a rapid evaluation of SARS-CoV-2 transmission in a community. We describe how a community group, the Yarmouth Wastewater Testing Team (YWTT), in Yarmouth, Maine, (population 8,990) utilized an asset-based community design ...
Yolanda M. Brooks, Bailey Gryskwicz, Eilidh Sidaway, Brianna Shelley, Laura Coroi, Margaret Downing, Tom Downing, Sharon McDonnell, Dan Ostrye, Katrina Hoop, Gib Parrish   +10 more
doaj   +1 more source

Viroinformatics investigation of B-cell epitope conserved region in SARS-CoV-2 lineage B.1.1.7 isolates originated from Indonesia to develop vaccine candidate against COVID-19 [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: SARS-CoV-2, a member of family Coronaviridae and the causative agent of COVID-19, is a virus which is transmitted to human and other mammals. Aims: To analyze the B-cell epitope conserved region and viroinformatics-based study of the SARS-CoV-
Arif N. M. Ansori, Reviany V. Nidom, Muhammad K. J. Kusala, Setyarina Indrasari, Irine Normalina, Astria N. Nidom, Balqis Afifah, Kartika B. Sari, Nor L. Ramadhaniyah, Mohammad Y. Alamudi, Umi Cahyaningsih, Kuncoro P. Santoso, Heri Kuswanto, Chairul A. Nidom   +13 more
doaj  

Vaccine trials during a pandemic: potential approaches to ethical dilemmas

Trials, 2021
Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge.
Manaf Alqahtani, Saad I. Mallah, Nigel Stevenson, Sally Doherty   +3 more
doaj   +1 more source