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Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021

open access: yesBulletin of the National Research Centre, 2021
Background Indonesia has started the big project of COVID-19 vaccination program since 13 January 2021 by employing the first shot of vaccine to the President of Indonesia as the outbreak and rapid transmission of COVID-19 have endangered not only ...
Reviany V. Nidom   +10 more
doaj   +1 more source

Delayed RT-PCR Time-To-Positivity in an adult with SARS-CoV-2 Infection

open access: yesJournal of Infection in Developing Countries, 2021
Early diagnosis is among the crucial measures to control the spread of SARS-CoV-2 infection. To date, reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for COVID-19 testing, but various factors can affect its performance ...
Nur Chandra Bunawan   +6 more
doaj   +1 more source

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

open access: yesNature Communications, 2022
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domain as ...
Christine E. Peters   +13 more
doaj   +1 more source

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

open access: yeseLife, 2023
SARS-CoV-2 spike protein plays a key role in mediating viral entry and inducing host immune responses. It can adopt either an open or closed conformation based on the position of its receptor-binding domain (RBD).
Qibin Geng   +9 more
doaj   +1 more source

The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes

open access: yesScientific Reports, 2021
The COVID-19 pandemic has affected more than 100 million cases and caused immense burdens on governments and healthcare systems worldwide. Since its emergence in December 2019, research has been focused on treating the infected, identifying those at risk
Marwa Ali Almadhi   +5 more
doaj   +1 more source

The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19

open access: yesInternational Journal of Infectious Diseases, 2021
Purpose: The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread.
Marwa Ali Almadhi   +6 more
doaj   +1 more source

A pneumonia outbreak associated with a new coronavirus of probable bat origin

open access: yesNature, 2020
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4.
P. Zhou   +28 more
semanticscholar   +1 more source

Clinical Characteristics of Coronavirus Disease 2019 in China

open access: yesNew England Journal of Medicine, 2020
Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.
W. Guan   +36 more
semanticscholar   +1 more source

COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study

open access: yesBMC Infectious Diseases, 2021
Background Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases.
Abdulkarim Abdulrahman   +2 more
doaj   +1 more source

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