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The COVID-19 pandemic has made German virologist Christian Drosten an unlikely cult figure.
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Risk factor targeting for vaccine prioritization during the COVID-19 pandemic
A key public health question during any disease outbreak when limited vaccine is available is who should be prioritized for early vaccination. Most vaccine prioritization analyses only consider variation in risk of infection and death by a single risk ...
Lloyd A. C. Chapman+8 more
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Protection from infection and reinfection due to the Omicron BA.1 variant in care homes
IntroductionFollowing the emergence of SARS-CoV-2 in 2020, care homes were disproportionately impacted by high mortality and morbidity of vulnerable elderly residents.
Saher Choudhry+10 more
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COVID-19, referred to as new coronary pneumonia, is an acute infectious disease caused by a new type of coronavirus SARS-CoV-2. To evaluate the effect of integrated Chinese medicine and Western medicine in patients with COVID-19 from overseas.
Yu-Xuan Huang+15 more
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It is hard to predict when vaccines against infection by SARSCoV-2 coronavirus may become available. The emergence of COVID-19 has led people to think that the best way of preventing it will be by using vaccines, as normally occurs when a new infectious disease appears.
Urbiztondo, L., Borràs, E., Mirada, G.
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Fluoxetine Can Inhibit SARS-CoV-2 In Vitro
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the coronavirus disease pandemic, drastically affecting global health and economy.
Arthur Dechaumes+7 more
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The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates
Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed that Nanosota-1 bound to the
Gang Ye+14 more
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Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
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