Results 81 to 90 of about 857,361 (295)

Severe acute respiratory syndrome (SARS): breathtaking progress [PDF]

, 2003
Reports of a new severe respiratory disease, now defined as severe acute respiratory syndrome (SARS), began to emerge from Guangdong, in southern China, in late 2002.
Bhagani, S, Gillespie, SH, Hawkey, PM
core   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Longitudinal analysis of SARS-CoV-2 IgG antibody durability in Puerto Rico

Scientific Reports
Understanding the dynamics of antibody responses following vaccination and SARS-CoV-2 infection is important for informing effective vaccination strategies and other public health interventions.
Zachary J. Madewell, Nathan E. Graff, Velma K. Lopez, Dania M. Rodriguez, Joshua M. Wong, Panagiotis Maniatis, Freddy A. Medina, Jorge L. Muñoz, Melissa Briggs-Hagen, Laura E. Adams, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Chelsea G. Major   +12 more
doaj   +1 more source

Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to ...
Douglas D. Fraser, MD, PhD, Marat Slessarev, MD, MSc, Claudio M. Martin, MD, MSc, Mark Daley, PhD, Maitray A. Patel, BSc, Michael R. Miller, PhD, Eric K. Patterson, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, David S. Wishart, PhD, Rupasri Mandal, PhD, Gediminas Cepinskas, DVM, PhD, On behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +26 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

A review of novel coronavirus infection (Coronavirus Disease-19)

Global Journal of Transfusion Medicine, 2020
Coronavirus (CoV) disease-2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome-CoV-2. The disease started in 2019 in Wuhan, China, and has spread globally, resulting in a pandemic. Common symptoms include fever, cough,
Neelesh Jain, Animesh Choudhury, Jayesh Sharma, Venkata Kumar, Divyendu De, Richa Tiwari   +5 more
doaj   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021

Scientific Reports
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020–September 2021.
Arnaud Drouin, Ian D. Plumb, Matthew McCullough, Jade James Gist, Sharon Liu, Marc Theberge, Joshua Katz, Matthew Moreida, Shelby Flaherty, Bhoomija Chatwani, Melissa Briggs Hagen, Claire M. Midgley, Dahlene Fusco   +12 more
doaj   +1 more source

Novel Outcome Biomarkers Identified With Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients

Critical Care Explorations, 2020
Objectives:. Coronavirus disease 2019 patients admitted to the ICU have high mortality. The host response to coronavirus disease 2019 has only been partially elucidated, and prognostic biomarkers have not been identified. We performed targeted proteomics
Douglas D. Fraser, MD, PhD, Gediminas Cepinskas, DVM, PhD, Eric K. Patterson, PhD, Marat Slessarev, MD, MSc, Claudio Martin, MD, MSc, Mark Daley, PhD, Maitray A. Patel, BSc, Michael R. Miller, PhD, David B. O’Gorman, PhD, Sean E. Gill, PhD, Guillaume Pare, MD, MSc, Ioannis Prassas, PhD, Eleftherios Diamandis, MD, PhD, on behalf of the Lawson COVID19 Study Team, Robert Arntfield, Ian Ball, Gordon Barkwell, Tracey Bentall, Karen Bosma, Saoirse Cameron, Eileen Campbell, David Carter, Carolina Gillio-Meina, Robert Hegele, Natalya Odoardi, Ram Singh, Kelly Summers, Sue Tereschyn   +27 more
doaj   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source