Results 161 to 170 of about 44,957 (175)

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

Nucleic Acids Research, 2010
An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are readily identifiable by comparative sequence analysis, but biochemical confirmation ...
Aartjan J W Te Velthuis, Jamie J Arnold, Craig E Cameron   +2 more
exaly   +3 more sources

Expression, purification, and characterization of SARS coronavirus RNA polymerase

Virology, 2005
The RNA-dependent RNA polymerase (RdRp) of SARS coronavirus (SARS-CoV) is essential for viral replication and a potential target for anti-SARS drugs. We report here the cloning, expression, and purification of the N-terminal GST-fused SARS-CoV RdRp and ...
Youhua Xie, Weihong Jiang, Eddy Arnold   +2 more
exaly   +2 more sources

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Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2

Nucleosides, Nucleotides & Nucleic Acids, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic of the coronavirus disease in 2019. RNA-dependent RNA polymerase (RdRp) plays an essential role in RNA replication and transcription in SARS-CoV-2. In this study, we focused on the RNA template component of viral RdRp structure and analyzed human microRNAs (miRNAs) targeting
Akira Sato, Yoko Ogino, Sei-ichi Tanuma, Fumiaki Uchiumi   +3 more
openaire   +2 more sources

Amoxicillin and Clavulanate as Potential Multiple Effect Inhibitors of 2019 Novel Coronavirus Main Protease and RNA-Dependent RNA Polymerase with Strong Receptor-Binding Domain (RBD), Molecular Docking and SAR Study

SSRN Electronic Journal, 2020
SARS-CoV-2 is a novel coronavirus was isolated and identified first time in 2019 in Wuhan, China. Nowadays, it is a worldwide danger and the WHO named it as a pandemic. With a number of 5,593,631 as confirmed cases, and 353,334 as deaths. On 17 February, we have started our researches for finding potential inhibitors for COVID-19 main protease ...
Khedidja benarous, Talia Serseg, Mohamed Yousfi   +2 more
openaire   +1 more source

In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2

Journal of Biomolecular Structure and Dynamics, 2022
Richard Mariadasse, Vijay Nirusimhan
exaly  

An Analysis of Inhibition of the Severe Acute Respiratory Syndrome Coronavirus 2 RNA-dependent Rna Polymerase By Zinc Ion: an in silico Approach

Future Virology, 2021
Sina Zoghi, Hossein Jafari Khamirani, Seyed Alireza Dastgheib   +2 more
exaly  

In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase

Journal of Biomolecular Structure and Dynamics, 2022
Vishal Singh, Mallikarjuna Rao Gedda, Amaresh Kumar Sahoo   +2 more
exaly  

Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent RNA polymerase (RdRp) inhibition: an in-silico analysis

Journal of Biomolecular Structure and Dynamics, 2021
Satyam Singh, Md Fulbabu Sk, Avinash Sonawane   +2 more
exaly  

RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

Biochemical and Biophysical Research Communications, 2021
Yi Jiang, Wanchao Yin, H Eric Xu
exaly  

RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19

Cancer Science, 2020
Mitsuhiro Machitani, Mami Yasukawa, Y Furuichi   +2 more
exaly