Results 61 to 70 of about 849,811 (296)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
RELATIONSHIP BETWEEN ORGANIZATIONAL CULTURE AND CULTURAL INTELLIGENCE [PDF]
This article examines one of the key competences of the 21st century, cultural intelligence. In our empirical research studies, we examined the cultural intelligence of full-time university students. We identified the corporate culture they would like to
Agnes BALOGH +2 more
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Corporate culture as an important factor in the implementation of knowledge management
Forum Scientiae Oeconomia, 2015 Knowledge and knowledge management are now increasingly seen as a critical part of the corporations. The increase development needs of corporate knowledge as well as innovative activities, whilst underlining the need and importance of corporate culture,
Jaroslava Bučková
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Does Corporate Culture Matter for Firm Policies? [PDF]
Economic theories suggest that a firm's corporate culture matters for its policy choices. We construct a parent-spinoff firm panel dataset that allows us to identify culture effects in firm policies from behavior that is inherited by a spinoff firm from ...
Cronqvist, Henrik +2 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Business, state, and community: 'responsible risk takers', New Labour, and the governance of corporate business [PDF]
, 2000 In December 1998, Peter Mandelson MP, one of the principal architects of the Labour Party’s victory in the May 1997 general election, dramatically resigned as Secretary of State for Trade and Industry. Nevertheless, despite his relatively brief period in
Wilson, G
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Iustinianus Primus Law Review, 2014 In this paper the authors systematically, detach, but do not separate, corporate culture from organizational culture. Further on corporate culture, from a theoretical viewpoint is established as a specific part of organizational culture, which ...
Aleksandar Klimovski, Timco Mucunski
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