Results 81 to 90 of about 4,675,991 (286)

Methodological approach to the optimization of management system selection in the sphere of industrial enterprises` corporate culture from position of its effectiveness [PDF]

open access: yesMarketing i Menedžment Innovacij, 2013
The aim of the article. The article presents the methodological approach to optimization of the choice of management actions in the sphere of corporate culture development from position of its economic efficiency.
M.I. Ovcharenko
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

The impact of gambling culture on corporate ESG performance: From the perspective of ESG rating disagreement

open access: yesInternational Review of Economics & Finance
Promoting corporate green transformation is crucial for the sustainable development of society. Using data from A-share listed corporates from 2009 to 2023, this study investigates whether and how gambling culture affects corporate environmental, social ...
Jiacong Ao, Xianrui Mo, Junyi Tian
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Whoever walks in integrity walks securely: does corporate integrity culture mitigate climate change exposure? [PDF]

open access: yes
This study examines the relationship between corporate integrity culture and firm-level climate change exposure. Using insights from social norm theory and a sample of 31,187 firm-year observations from US firms between 2001 and 2021, we conclude that ...
Puwanenthiren, P.   +7 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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