Results 91 to 100 of about 8,778,792 (221)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

ESG rating, corporate dividends policy, and the moderating role of corporate life cycle: Cross country study

International Studies of Economics
This article investigates the link between environmental, social, and governance performance (ESG) and dividend policy, as well as how likely the corporate life cycle might moderate this association.
Husam Ananzeh, Amin Khalifeh, Hamza Alqudah, Hassan Ali Al‐Ababneh, Hamzeh Al Amosh   +4 more
doaj   +1 more source

MODEL KEBIJAKAN DIVIDEN BERDASARKAN SIKLUS HIDUP PERUSAHAAN: STUDI EMPIRIS DI INDONESIA

Jurnal Benefita, 2018
In the life cycle theory of the company, it is stated that the Company which is at the established stage has the ability to make money beyond its ability to find profitable investment opportunities.
Irdha Yusra, Lisa Amelia Herman, Nova Begawati   +2 more
doaj   +1 more source

Corporate Social Responsibility, Corporate Life Cycle, and Dividend Policy

Journal of Accounting, Business and Management (JABM), 2020
The aim of this paper is to investigate the impact of corporate social responsibility(CSR) on dividend policy through corporate life cycle (CLC) as a mediator using pathanalysis for 308 firms-observation for 80 non-financial firms during the period from 2014to 2017 using smart PLS (partial least square).
openaire   +2 more sources

Introduction to “Life Cycle Inventory Analysis”

, 2021
This chapter introduces the life cycle inventory (LCI) analysis – the topic of this volume. A brief history of the concept is provided, including its procedure according to different standards and guidance books.
Ciroth, Andreas,, Rickard Arvidsson, Andreas Ciroth, Arvidsson, Rickard,   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Corporate life cycle, organizational financial resources and corporate social responsibility

, 2017
© 2017 Elsevier LtdThis study examines the association between the corporate life cycle and corporate social responsibility (CSR). Motivated by the resource-based theory, we hypothesize and find supportive evidence that the resource base and competitive ...
Mostafa Monzur Hasan, Hasan, Mostafa, Ahsan Habib, Habib, A.   +3 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Determination of HSE program proportional to organizational Corporate life cycles

بهداشت و ایمنی کار, 2013
Introduction: Nowadays,industries managers face to lots of information from internal and external sources in one hand,challenges andthreats in the other hand, that need proper decisions to fix the problems.
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doaj