Results 41 to 50 of about 17,085 (296)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Environmentally conscious design : an economic life cycle approach [PDF]
, 1997 Companies are under increasing pressure to deal with environmental concerns during product design, for it is the design process which primarily decides the environmental impact of a manufactured product over its life.
Rose, Elliot P., Rose, E.P.
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Sustainable FuturesWater scarcity is a growing global issue, making corporate water management increasingly critical. Although the literature on corporate water disclosure is growing, existing studies remain limited and mainly focus on governance-driven determinants ...
Octa Marselita, Ratna Wardhani
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Product Life Cycles in Corporate Finance
The Review of Financial Studies, 2018 AbstractWe develop a novel 10-K text-based model of product life cycles and examine firm investment policies. Conditioning on the life cycle substantially improves the power of q to explain investment and reveals a natural ordering of investments over the life cycle.
Gerard Hoberg, Vojislav Maksimovic
openaire +1 more source
Corporate life cycle, organizational financial resources and corporate social responsibility
, 2017 © 2017 Elsevier LtdThis study examines the association between the corporate life cycle and corporate social responsibility (CSR). Motivated by the resource-based theory, we hypothesize and find supportive evidence that the resource base and competitive ...
Mostafa Monzur Hasan +3 more
core +1 more source
Corporate Governance in IPOs [PDF]
, 2013 It is increasingly recognized in the management literature that the initial public off ering (IPO) is an important stage in the life cycle of privately held and entrepreneurial fi rms.
Filatotchev, Igor +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source