Results 61 to 70 of about 437,448 (305)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A terminal assessment of stages theory : introducing a dynamic states approach to entrepreneurship [PDF]

, 2009
Stages of Growth models were the most frequent theoretical approach to understanding entrepreneurial business growth from 1962 to 2006; they built on the growth imperative and developmental models of that time. An analysis of the universe of such models (
Afuah A., Aldrich H., Ancona D., Anderson P., Autio E., Axelrod R., Baron R.A., Bhidé A., Birch D., Birch D.L., Birley S., Chandler A.D., Christensen C.R., Churchill N.C., Dean J., Dhalla N.K., Dubin R., Eggers J.H., Epstein M.J., Gardner J.W., Gartner W., Greiner L., Greiner L., Gupta Y.P., Hanks S.H., Hawken P., Holland J., Kauffman S., Kaufman H., Kimberly J.R., Kuratko D.F., Leibenstein H., Lichtenstein B., Lippitt G.L., Marshall A., Meyer A., Nicholls–Nixon C., Normann R., Pennings J., Penrose E., Prigogine I., Reynolds P.D., Rhenman E., Rostow W.W., Sahlman W.A., Schaltegger S., Schoonhoven C.B., Schori T.R., Schrödinger E., Scott B.R., Scott R., Senge P., Small Business Administration, Starbuck W.H., Stevenson H., Thompson J., Timmons J.A., Toynbee A.J., Tushman M.L., Webster's   +59 more
core   +2 more sources

The Life Cycle of Corporate Venture Capital [PDF]

SSRN Electronic Journal, 2015
AbstractThis paper investigates why industrial firms conduct Corporate Venture Capital (CVC) investment in entrepreneurial companies. I test alternative views on CVC by exploiting the entry, investment, and termination decisions of CVC divisions. CVC entry concentrates in firms that experience deteriorations of internal innovation.
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The role of the hierarchical theory in explaining the capital structure of the firms based on enterprise life cycle model [PDF]

Accounting, 2016
Capital structure is a controversial issue in the field of corporate finance. There are several studies to find a way to determine the optimal capital structure to minimize the cost of capital and maximize the corporate value.
Jamal Bahiri Saleth, Abbas Aalizadeh
doaj   +1 more source

Модели жизненного цикла программного обеспечения при разработке корпоративных информационных систем технологичекой подготовки производства [PDF]

, 2011
Рассматривается эффективность использования моделей жизненного цикла разработки программного обеспечения в соответствии с международным стандартом ISO/IEC 12207:1995 “Information Technology – Software Life Cycle Processes” для разработки программного ...
Бортникова, В. О., Евсеев, В. В., Невлюдов, И. Ш.   +2 more
core  

Corporate Social Responsibility, Corporate Life Cycle, and Dividend Policy

Journal of Accounting, Business and Management (JABM), 2020
The aim of this paper is to investigate the impact of corporate social responsibility(CSR) on dividend policy through corporate life cycle (CLC) as a mediator using pathanalysis for 308 firms-observation for 80 non-financial firms during the period from 2014to 2017 using smart PLS (partial least square).
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Economic Value Added as a Dependence on the Corporate- and Market-life Cycle [PDF]

, 2011
Economic value added (EVA) is an indicator which is widely used as the main tool for financial analysis. There are two methods of calculating it. The original method which was made by Stern & Stewart is defined as the net operating profit after taxes ...
Konečný Zdeněk
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source