Results 61 to 70 of about 922,494 (289)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

THE CRIMINAL LIABILITY OF CORPORATIONS – OVERVIEW ON RECENT CASE LAW OF THE ROMANIAN COURTS [PDF]

Challenges of the Knowledge Society, 2012
Although the criminal liability of corporations is now consecrated in Romanian for more than five years, there is however some reticence in engaging the liability of such person. Nonetheless, in the past years, it can be noticed an emergence of the files
ANDRA ROXANA ILIE
doaj  

Design for Giving: Understanding What Motivates Corporate Philanthropy [PDF]

, 2003
What motivates corporate philanthropy? Since corporate giving is often fragmented, both in the sense of where grants originate within a company and where they are distributed, corporations typically lack a clear and comprehensive picture of their overall
John Kania, Mindy W. Oakley
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

PROFIT VERSUS INSOLVENCY IN ROMANIAN ECONOMY [PDF]

Annals of the University of Petrosani: Economics, 2010
The recession has affected a proportion of 6-7% in Romania, whichconfronted with the consequences of current deficit and sizable debts in foreign currency.Under these circumstances, Romanian companies faced big difficulties, therefore just a littlepart ...
GABRIELA CORINA SLUSARIUC, ANCA JAMILA GUŢĂ   +1 more
doaj  

‘Public enemy no. 1’: Tobacco industry funding for the AIDS response

SAHARA-J, 2016
This article analyzes the history of tobacco industry funding for the AIDS response – a largely ignored aspect of private donor involvement. Primary documents from the Legacy Tobacco Documents Library and AIDS organizations are analyzed, alongside ...
Julia Smith, Sheryl Thompson, Kelley Lee
doaj   +1 more source

Making an impact: The influence of policies to reduce emissions from aviation on the business travel patterns of individual corporations [PDF]

, 2010
The contribution of aviation to global carbon dioxide (CO2) emissions is projected to triple by 2050. As nations strive to meet CO2 reduction targets, policy interventions to manage the growth of emissions arising from air travel are likely.
Dillman, Lu, López-Gamero, MEA, Paul R. Armsworth, Vedantham, Zoe G. Davies   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Performance and Marketing Strategy of Micro, Small, and Medium Enterprises of Cashew Nut Processing (A Case in CV Hukasari Semesta in Muna, Indonesia) [PDF]

International Journal of Industrial Engineering and Production Research
Cashew nuts, a plantation commodity from Indonesia, come with a high economic value. Cashew nut processing enterprises are crucial in elevating the value added, broadening the work field, and enhancing labor absorption. This research provides an analysis
La Sinaini, S Saptana, Sri Bananiek, Bungati Bungati   +3 more
doaj  

Everything in moderation? The effect of extremist nominations on individual and corporate PAC fundraising

Political Science Research and Methods
Do ideologically extreme candidates enjoy fundraising advantages over more moderate candidates? Extant work documents a relationship between candidates’ positions and campaign contributions subnationally and in donor surveys, yet identification ...
Mellissa Meisels
doaj   +1 more source