Results 91 to 100 of about 4,680,147 (302)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Scale-dependent correction to the dynamical conductivity of a disordered system at unitary symmetry

, 2012
Anderson localization has been studied extensively for more than half a century. However, while our understanding has been greatly enhanced by calculations based on a small epsilon expansion in d = 2 + epsilon dimensions in the framework of non-linear ...
Muttalib, K. A., Nakayama, T., Ostrovsky, P. M., Wölfle, P.   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dynamic Stimulation Aberrometry

Ophthalmology Science
Purpose: Anterior iris-claw phakic intraocular lens (pIOL) implantation is a treatment option for refractive, ametropic patients. However, the postoperative accommodative ability has not been systematically researched.
Maximilian Hammer, MD, Yvonne Heggemann, MSc, Gerd U. Auffarth, MD, PhD   +2 more
doaj   +1 more source

Herpes zoster ophthalmicus-induced oculomotor nerve palsy

Journal of Optometry, 2013
Herpes zoster ophthalmicus (HZO) may cause a variety of ocular conditions including: dermatitis, corneal pseudo-dendrites, uveitis, retinitis, and cranial nerve palsies.
Jennifer S. Harthan, Christopher J. Borgman   +1 more
doaj   +1 more source

Average luminosity distance in inhomogeneous universes

, 2010
The paper studies the correction to the distance modulus induced by inhomogeneities and averaged over all directions from a given observer. The inhomogeneities are modeled as mass-compensated voids in random or regular lattices within Swiss-cheese ...
A. Fairall, A. Ishibashi, A. Lemaître, A. Sandage, A. Sandage ., A.G. Riess ., B. Granett, B.R. Granett, C. Foster, D.D. Kocevski, G. Ellis, H. Bondi, H.G. Rose, HST collaboration, I. Zehavi, J. Neill, J. Silk, J.A. Willick, J.R. Mould ., K. Van Acoleyen, L. da Costa ., M. Einasto ., M. Hicken ., N. Brouzakis, N. Mustapha, P.J.E. Peebles, R. Giovanelli ., R. Kessler ., S. Jha, T. Haugboelle ., V. Marra, V. Mukhanov, Valentin Kostov, W. Valkenburg, X. Shi, X.-D. Shi   +35 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Psychological diagnostics of risky behavior of adolescents

Психіатрія, неврологія та медична психологія, 2020
The article reflects practical results of the research on adolescent risky behavior and specifically – the psychodiagnostics stage. Traditionally therapeutic impact on risky adolescents is not quite effective.
Anastasiia Rakhimkulova
doaj  

$O(\alpha^2 G_F m^2_t)$ Contributions to $H\to\gamma\gamma$

, 1996
The rare decay $H\to \gamma\gamma$ is a promising detection channel for an intermediate mass Higgs boson. We compute its two-loop $O(\alpha^2 G_F m_t^2)$ correction in the standard model and find that the relative correction to the decay rate runs ...
Abbott, Baer, Dawson, Dawson, Dawson, Deshpande, Djouadi, Djouadi, Djouadi, Djouadi, Donoghue, Eichten, Ellis, Georgi, Georgi, Georgi, Glashow, Graudenz, Gunion, Gunion, Haber, Hoogeveen, Kleiss, Kunszt, Kunszt, Liao, Marciano, McWilliams, Melnikov, Salam, Weinberg, Xiayuan Li, Yi Liao, Zheng   +33 more
core   +1 more source