Results 91 to 100 of about 6,018,350 (361)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A generally applicable atomic-charge dependent London dispersion correction.

Journal of Chemical Physics, 2018
The so-called D4 model is presented for the accurate computation of London dispersion interactions in density functional theory approximations (DFT-D4) and generally for atomistic modeling methods.
Eike Caldeweyher, S. Ehlert, A. Hansen, Hagen Neugebauer, S. Spicher, Christoph Bannwarth, S. Grimme   +6 more
semanticscholar   +1 more source

Yukawa correction to top-quark production at the Tevatron

, 1993
We calculate the correction to $\qbq\to\tbt$ of order $\gmm$. This correction, proportional to the square of the Higgs-boson Yukawa coupling to the top quark, arises from loops of Higgs bosons and the scalar component of virtual vector bosons. The Yukawa
A. Denner, A. Stange, B. Adeva, C.-P. Yuan, D. Carlson, D. Ross, D. Toussaint, E. Laenen, F. Berends, G. J. van Oldenborgh, G. Passarino, J. Feigenbaum, J. Gunion, J. Hewett, J. Morfin, J. Ng, J. Owens, M. Akrawy, M. Battle, M. Chanowitz, M. Strassler, M. Veltman, P. Abreu, P. Kim, P. Nason, R. Guth, R. K. Ellis, R. K. Ellis, S. Bertolini, S. Bertolini, S. Glashow, S. Willenbrock, S. Willenbrock, V. Barger, V. Barger, W. Beenakker, W. Beenakker, W. Beenakker, W. Marciano, Z. Kunszt   +39 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Preoperative edema severity affects outcomes after Descemet membrane endothelial keratoplasty for Fuchs endothelial corneal dystrophy: a cohort study

Eye and Vision
Background In patients with Fuchs endothelial corneal dystrophy (FECD), the most beneficial stage to perform Descemet membrane endothelial keratoplasty (DMEK) remains uncertain.
Maximilian Friedrich, Hyeck-Soo Son, Jasper Lind, Maximilian Hammer, Lizaveta Chychko, Timur Mert Yildirim, Gerd Uwe Auffarth, Victor Aristide Augustin   +7 more
doaj   +1 more source

Diagnosis of Congenital Diaphragmatic Hernia in Fetuses and Newborns

Zdorovʹe Rebenka, 2012
The article deals with an urgent problem of pediatric surgery — congenital diaphragmatic hernia (СDН) in newborns. 64 case histories of children with СDН, underwent medical treatment in State Institution «Institute of Pediatrics, Obstetrics and ...
O.K. Slyepov, I.Yu. Gordiyenko, O.P. Ponomarenko, O.M. Tarapurova, V.P. Soroka, A.V. Velychko, O.P. Dzham, L.V. Golovchenko, L.V. Silayeva   +8 more
doaj   +1 more source

Gravitational Corrections to $\Phi^{4}$ Theory with Spontaneously Broken Symmetry

, 2012
We consider a complex scalar $\Phi^4 $ theory with spontaneously broken global U(1) symmetry, minimally coupling to perturbatively quantized Einstein gravity which is treated as an effective theory at the energy well below the Planck scale.
B. S. DeWitt, D. Bardin, G. ’t Hooft, Hao-Ran Chang, Wen-Tao Hou, Yi Sun   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Clinical Performance After Implantation of a New Purely Refractive Extended Depth of Field Intraocular Lens in Cataract Patients

Clinical Ophthalmology
Gerd Uwe Auffarth,1 Alexandra-Teodora Negoescu,1 Frederick Kremser,1 Lizaveta Chychko,1 Lusine Vogormian,1 Ramin Khoramnia,1,2 Timur M Yildirim1 1Department of Ophthalmology, Heidelberg University Hospital, Heidelberg, Germany; 2Department of ...
Auffarth GU, Negoescu AT, Kremser F, Chychko L, Vogormian L, Khoramnia R, Yildirim TM   +6 more
doaj  

Correction: Review of electrical energy storage technologies, materials and systems: challenges and prospects for large-scale grid storage

, 2018
Correction for ‘Review of electrical energy storage technologies, materials and systems: challenges and prospects for large-scale grid storage’ by Turgut M. Gur, Energy Environ. Sci., 2018, DOI: 10.1039/c8ee01419a.
T. M. Gür
semanticscholar   +1 more source