Results 81 to 90 of about 1,203,995 (286)

Indirect correlative light and electron microscopy (iCLEM) : a novel pipeline for multiscale quantification of structure from molecules to organs

Correlative light and electron microscopy (CLEM) methods are powerful methods that combine molecular organization (from light microscopy) with ultrastructure (from electron microscopy).
Chen, Zhenhui, Vanslembrouck, Bieke, Struckman, Heather L., Moise, Nicolae, Struckman, Heather L, van Hengel, Jolanda, Weinberg, Seth H, Rothacker, Nathan, Veeraraghavan, Rengasayee, Weinberg, Seth H.   +9 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Adapting an in situ X-ray CT compression stage for pull-out testing: Methodological development and characterization of failure evolution in Ni/PU hybrid foams

European Journal of Materials
The integration of metallic fasteners into cellular hybrid materials presents significant challenges regarding interface integrity and localized load transfer. This study is exploratory in nature, focusing on the methodological development and evaluation
Jonas Fell, Hendrik Jost, Dionne Schnubel, Maurice Großelindemann, Marius Weiler, Anne Jung, Hans-Georg Herrmann   +6 more
doaj   +1 more source

Ultrastructure and nuclear architecture of telomeric chromatin revealed by correlative light and electron microscopy

, 2022
This dataset contains data pertinent to Hübner et al., NAR, 2022: Ultrastructure and nuclear architecture of telomeric chromatin revealed by correlative light and electron ...
Ahsan, Bilal, Hübner, Barbara, Ludwig, Alexander, Henriksson, Sara, Sandin, Sara, Wee, Mei Ling, von Otter, Eric   +6 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

High-resolution correlative imaging in ultrafast electron microscopy

Advances in Physics: X
Ultrafast electron microscopy (UEM) has a broad scope of application across material systems and scientific disciplines. In UEM, we investigate multiscale dynamics in the spatial domain ranging from micrometres to ångströms, in reciprocal space, and on ...
Ye-Jin Kim, Won-Woo Park, Hak-Won Nho, Oh-Hoon Kwon   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences [PDF]

Appl Phys Lett, 2023
Bosch C, Lindenau J, Pacureanu A, Peddie C, Majkut M, Douglas A, Carzaniga R, Rack A, Collinson L, Schaefer A, Stegmann H.   +10 more
europepmc   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

3D HDO-CLEM: cellular compartment analysis by correlative light-electron microscopy on cryosections.

, 2017
Fundamental to obtaining a depth-understanding of the function and structure of cells is the ability to study and correlate their molecular topography with the ultrastructural morphology, for example, to visualize the position of a given protein relative
Vicidomini G, Boccacci P, Diaspro A, Tacchetti C., Cortese K, Gagliani MC   +5 more
core   +1 more source