Novel Pathway for Corrinoid Compounds Production in Lactobacillus [PDF]
Frontiers in Microbiology, 2018 Vitamin B12 or cobalamin is an essential metabolite for humans, which makes it an interesting compound for many research groups that focus in different producer-strains synthesis pathways.
Andrea Carolina Torres +4 more
doaj +10 more sources
Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy [PDF]
mBio, 2022 In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy +6 more
doaj +5 more sources
Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches [PDF]
mBio, 2023 The ability to sense and respond to intracellular metabolite levels enables cells to adapt to environmental conditions. Many prokaryotes use riboswitches—structured RNA elements usually located in the 5′ untranslated region of mRNAs—to sense ...
Rebecca R. Procknow +4 more
doaj +5 more sources
Axial Ligation and Redox Changes at the Cobalt Ion in Cobalamin Bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in Solution Characterized by XAS and DFT. [PDF]
PLoS ONE, 2016 A cobalamin (Cbl) cofactor in corrinoid iron-sulfur protein (CoFeSP) is the primary methyl group donor and acceptor in biological carbon oxide conversion along the reductive acetyl-CoA pathway.
Peer Schrapers +6 more
doaj +9 more sources
Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex [PDF]
Communications Biology, 2023 Structures of Methanosarcina barkeri trimethylamine methyltransferase (MttB) with its substrates reveal the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.
Jiaxin Li +6 more
doaj +3 more sources
Functional genomics of corrinoid starvation in the organohalide-respiring bacterium Dehalobacter restrictus strain PER-K23 [PDF]
Frontiers in Microbiology, 2015 De novo corrinoid biosynthesis represents one of the most complicated metabolic pathways in nature. Organohalide-respiring bacteria (OHRB) have developed different strategies to deal with their need of corrinoid, as it is an essential cofactor of ...
Aamani eRupakula +6 more
doaj +3 more sources
Genetic Analysis of Citrobacter sp.86 Reveals Involvement of Corrinoids in Chlordecone and Lindane Biotransformations [PDF]
Frontiers in Microbiology, 2020 Chlordecone (Kepone®) and γ-hexachlorocyclohexane (γ-HCH or lindane) have been used for decades in the French West Indies (FWI) resulting in long-term soil and water pollution. In a previous work, we have identified a new Citrobacter species (sp.86) that
Agnès Barbance +11 more
doaj +2 more sources
Kinetic and substrate complex characterization of RamA, a corrinoid protein reductive activase from Methanosarcina barkeri. [PDF]
FEMS Microbiology Letters, 2020 In microbial corrinoid-dependent methyltransferase systems, adventitious Co(I)-corrinoid oxidation halts catalysis and necessitates repair by ATP-dependent reductive activases.
Katherine A Huening +2 more
semanticscholar +2 more sources
The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales. [PDF]
Annu Rev MicrobiolMicrobial communities in different environments have major impacts on global nutrient cycling and on the health of host organisms. However, the complexity of microbial communities complicates the investigation of how interactions among numerous microbial
Alvarez-Aponte ZI, Procknow RR, Taga ME.
europepmc +2 more sources
Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins [PDF]
eLife, 2018 Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Aaron G Wexler +5 more
doaj +3 more sources