Results 11 to 20 of about 2,324 (198)

Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities [PDF]

Environmental Microbiology, 2014
Summary Cobalamin and other corrinoids are essential cofactors for many organisms. The majority of microbes with corrinoid‐dependent enzymes do not produce corrinoids de novo , and instead must acquire corrinoids produced by other organisms in their environment. However, the
Men, Yujie, Seth, Erica C, Yi, Shan, Crofts, Terence S, Allen, Robert H, Taga, Michiko E, Alvarez-Cohen, Lisa   +6 more
openaire   +6 more sources

Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex

Communications Biology, 2023
Structures of Methanosarcina barkeri trimethylamine methyltransferase (MttB) with its substrates reveal the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.
Jiaxin Li, Patrick T. Kang, Ruisheng Jiang, Jodie Y. Lee, Jitesh A. Soares, Joseph A. Krzycki, Michael K. Chan   +6 more
doaj   +2 more sources

Vitamin B12 and Reproductive Health: Clinical Insights, Emerging Mechanistic Understanding, and Nutritional Aspects. [PDF]

Mol Reprod Dev
ABSTRACT Epidemiological data from assisted reproductive technologies (ART) link vitamin B12 (VitB12) deficiency to shorter gestation, low birth weight, and reduced live birth rates. VitB12 also plays a critical role in fertility for both sexes by supporting gamete quality.
Mathew AR, Selita E, Regano C, Bianco C, Corsetti V, Cavallucci V, Moreno S, Tata AM, Fidaleo M.   +8 more
europepmc   +2 more sources

Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

mBio, 2022
In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina V. Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga   +6 more
doaj   +1 more source

Pseudovitamin B₁₂ producing Loigolactobacillus coryniformis enhances soy milk fermentation by Lactobacillus delbrueckii subsp. bulgaricus. [PDF]

J Sci Food Agric
Abstract BACKGROUND Fermenting soy milk with lactic acid bacteria is challenging. Generally, carbohydrates are added to enhance the acid production in soy milk. However, the yoghurt starter Lactobacillus delbrueckii subsp. bulgaricus did not succeed in fermenting soy milk supplemented with carbohydrates.
Tsuda H, Iwai K, Hayashizaki N.
europepmc   +2 more sources

The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales [PDF]

Annual Review of Microbiology
Michiko Taga
exaly   +2 more sources

Four families of folate-independent methionine synthases.

PLoS Genetics, 2021
Although most organisms synthesize methionine from homocysteine and methyl folates, some have "core" methionine synthases that lack folate-binding domains and use other methyl donors.
Morgan N Price, Adam M Deutschbauer, Adam P Arkin   +2 more
doaj   +1 more source

Corrinoids in anaerobic bacteria [PDF]

FEMS Microbiology Letters, 1990
C1-metabolizing bacteria were analyzed for their corrinoids. The autotrophic phototrophe Chloroflexus aurantiacus contains predominantly the light-sensitive coenzyme B12. The corrinoid could be teh prostethic group of a methylmalonyl-CoA mutase, which is involved in the CO2 fixing reaction sequence from proplonyl-CoA to succinyl CoA.
Erhard Stupperich, Hans-Jürgen Eisinger, Sabine Schurr   +2 more
openaire   +2 more sources

Interspecies transfer of biosynthetic cobalamin for complete dechlorination of trichloroethene by Dehalococcoides mccartyi

Water Science and Technology, 2022
Complete dechlorination of trichloroethene (TCE) by Dehalococcoides mccartyi is catalyzed by reductive dehalogenases (RDases), which possess cobalamin as the crucial cofactor. However, virtually all D. mccartyi isolated thus far are corrinoid auxotrophs.
Haijun Li, Shanming Wei, Na Liu, Yalu Du, Guantao Ding   +4 more
doaj   +1 more source

Genetic Analysis of Citrobacter sp.86 Reveals Involvement of Corrinoids in Chlordecone and Lindane Biotransformations

Frontiers in Microbiology, 2020
Chlordecone (Kepone®) and γ-hexachlorocyclohexane (γ-HCH or lindane) have been used for decades in the French West Indies (FWI) resulting in long-term soil and water pollution. In a previous work, we have identified a new Citrobacter species (sp.86) that
Agnès Barbance, Oriane Della-Negra, Sébastien Chaussonnerie, Valérie Delmas, Delphine Muselet, Edgardo Ugarte, Pierre-Loïc Saaidi, Jean Weissenbach, Cécile Fischer, Denis Le Paslier, Nuria Fonknechten, Nuria Fonknechten   +11 more
doaj   +1 more source