Results 51 to 60 of about 6,476,215 (305)

Cortical activity of relevance [PDF]

, 2019
Many theoretical approaches in information retrieval assume that relevance is based on mutual interaction of the system and user. Past studies have mainly focused on the system side of relevance, while user-centred studies are more recent. As a result, this work aims to focus on user relevance, which is characterised as a subjective process, dependant ...
Pinkosova, Zuzana, Moshfeghi, Yashar
openaire   +2 more sources

Adrenal cortical activity in depression

Comprehensive Psychiatry, 1968
Summary We have presented a pilot study of ten depressed patients as well as preliminary data from another study which suggests alternations in the diurnal pattern of steroid excretion in depression. We found evidence that the patient's own rating of his affect may be an accurate predictor of increased adrenal cortical activity.
D T, Fullerton, F N, Lohrenz, H, Fahs, F, Wenzel   +3 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of alprazolam on cortical activity and tremors in patients with essential tremor. [PDF]

PLoS ONE, 2014
BACKGROUND: Essential tremor (ET) is characterised by postural and action tremors with a frequency of 4-12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways.
Jaime Ibáñez, Jesús González de la Aleja, Juan A Gallego, Juan P Romero, Rosana A Saíz-Díaz, Julián Benito-León, Eduardo Rocon   +6 more
doaj   +1 more source

Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity [PDF]

Proceedings of the National Academy of Sciences, 2005
Accurate interpretation of functional MRI (fMRI) signals requires knowledge of the relationship between the hemodynamic response and the neuronal activity that underlies it. Here we address the question of coupling between pre- and postsynaptic neuronal activity and the hemodynamic response in rodent somatosensory (Barrel) cortex in response to single ...
Anna, Devor, Istvan, Ulbert, Andrew K, Dunn, Suresh N, Narayanan, Stephanie R, Jones, Mark L, Andermann, David A, Boas, Anders M, Dale   +7 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Neuronal Activity Patterns Regulate Brain-Derived Neurotrophic Factor Expression in Cortical Cells via Neuronal Circuits

Frontiers in Neuroscience, 2021
During development, cortical circuits are remodeled by spontaneous and sensory-evoked activity via alteration of the expression of wiring molecules. An intriguing question is how physiological neuronal activity modifies the expression of these molecules ...
Yumi Miyasaka, Nobuhiko Yamamoto
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Electroencephalographic changes after one nigth of sleep deprivation Respostas eletrencefalográficas após uma noite de privação de sono

Arquivos de Neuro-Psiquiatria, 2006
Total or partial sleep deprivation (SD) causes degrading effects on different cognitive and psychomotor functions that might be related to electrophysiological changes frequently observed. In the present study, we investigated the effects of one night of
Camila Ferreira, Andréa Deslandes, Helena Moraes, Maurício Cagy, Fernando Pompeu, Luis Fernando Basile, Roberto Piedade, Pedro Ribeiro   +7 more
doaj   +1 more source