Results 71 to 80 of about 6,476,215 (305)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Coordinated optimization of visual cortical maps : 2. Numerical studies [PDF]

, 2012
In the juvenile brain, the synaptic architecture of the visual cortex remains in a state of flux for months after the natural onset of vision and the initial emergence of feature selectivity in visual cortical neurons. It is an attractive hypothesis that
Heide, Dominik, Justin C. Crowley (120185), Wolf, Fred, Dominik Heide, Fred Wolf, Matthias Kaschube, Löwel, Siegrid, Crowley, Justin C., Kaschube, Matthias, Dominik Heide (120181), Justin C Crowley, Reichl, Lars, Lars Reichl, Lars Reichl (120178), Siegrid Löwel, Siegrid Löwel (53603), Fred Wolf (120189), Matthias Kaschube (120187)   +17 more
core   +1 more source

Efficacy evaluation of functional motor regulation method with mathematical analysis of EEG [PDF]

Саратовский научно-медицинский журнал, 2011
Effects of functional motor regulation method have been measured using the spectral and coherent EEG. Obtained results have fully confirmed the hypothesis that the clinical effectiveness of the method is associated with the formation of new regulatory ...
Laisheva О.А., Kiselev D.A., Balabanova V.A., Gubanov V.V.   +3 more
doaj  

Cortical activation elicited by unrecognized stimuli [PDF]

Behavioral and Brain Functions, 2006
Abstract Background It is unclear whether a stimulus that cannot be recognized consciously, could elicit a well-processed cognitive response. Methods We used functional imaging to examine the pattern of cortical activation elicited by unrecognized stimuli during memory ...
openaire   +5 more sources

Baroreceptor stimulation alters cortical activity [PDF]

Psychophysiology, 1993
AbstractThe arterial baroreceptors constitute an essential sensory link for the short‐term regulation of blood pressure and may also influence higher cortical function. The present study was undertaken to evaluate previous reports of such a cortical influence under conditions of psychologically controlled, mechanical baroreceplor stimulation.
Rau, Harald, Pauli, Paul, Brody, Stuart, Birbaumer, Niels, Elbert, Thomas   +4 more
openaire   +4 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Striatal prediction error modulates cortical coupling [PDF]

, 2010
Both perceptual inference and motor responses are shaped by learned probabilities. For example, stimulus-induced responses in sensory cortices and preparatory activity in premotor cortex reflect how (un)expected a stimulus is.
Ouden, H.E.M. den, Roiser, J., den Ouden, H.E.M., den Ouden, H E M, Daunizeau, J, Friston, K J, J. Roiser, K. E. Stephan, Stephan, K.E., H. E. M. den Ouden, K. J. Friston, Stephan, K E, J. Daunizeau, Daunizeau, J., Friston, K.J., Roiser, J   +15 more
core   +2 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Semantic Cortical Activation in Dyslexic Readers

Journal of Cognitive Neuroscience, 1999
AbstractThe combined temporal and spatial resolution of MEG (magnetoencephalography) was used to study whether the same brain areas are similarly engaged in reading comprehension in normal and developmentally dyslexic adults. To extract a semantically sensitive stage of brain activation we manipulated the appropriateness of sentence-ending words to the
Helenius, Päivi, Salmelin, Riitta, Service, Elisabet, Connolly, John F.   +3 more
openaire   +3 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source