Results 61 to 70 of about 6,476,215 (305)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Causal hierarchy within the thalamo-cortical network in spike and wave discharges [PDF]

, 2009
Background: Generalised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption of ongoing activities and impaired consciousness, occurring during states of ...
Lemieux, L., Vaudano, Anna E., Friston, KJ, Rodionov Roman, Carmichael, D., Thornton, R., Thornton, Rachel, Lemieux, Louis, VAUDANO, Anna Elisabetta, Maxime Guye, Vaudano, A., Vaudanao, A. E., Anna E Vaudano, Carmichael, David W., Hamandi, K., Carmichael David W., Kiebel, SJ, Carmichael, DW, Vaudano Anna E., Vaudano, AE, Guye, M, Hamandi, K, Thornton Rachel, Guye Maxime, Duncan, JS, de la Prida, Liset Menendez, Friston Karl J., Louis Lemieux, Stefan J Kiebel, Rachel Thornton, Rodionov, R, David W Carmichael, Khalid Hamandi, Friston, Karl J., Thornton, R, Duncan, John, Guye, M., Kiebel, Stefan J., Duncan, John S., Rodionov, Roman, Duncan, J., Duncan John S., Lemieux, L, Roman Rodionov, Hamandi Khalid, Kiebel, S., Hamandi, Khalid, Lemieux Louis, Friston, K., Rodionov, R., Laufs, H, Laufs, Helmut, Carmichael, D. W., Helmut Laufs, Laufs, H., John S Duncan, Laufs Helmut, Guye, Maxime, Karl J Friston, Kiebel Stefan J.   +59 more
core   +1 more source

Cortical computations via metastable activity [PDF]

Current Opinion in Neurobiology, 2019
Metastable brain dynamics are characterized by abrupt, jump-like modulations so that the neural activity in single trials appears to unfold as a sequence of discrete, quasi-stationary states. Evidence that cortical neural activity unfolds as a sequence of metastable states is accumulating at fast pace.
La Camera, Giancarlo, Fontanini, Alfredo, Mazzucato, Luca   +2 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

How Inhibition Shapes Cortical Activity [PDF]

Neuron, 2011
Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is necessary for our understanding of cortical function. We
Isaacson, Jeffry S., Scanziani, Massimo
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Differential cortical responses to neuromuscular electrical vs. peripheral magnetic stimulation: a multimodal TMS-fNIRS study

Frontiers in Neuroscience
ObjectiveTo investigate cortical modulatory effects of neuromuscular electrical stimulation (NMES) and peripheral magnetic stimulation (PMS) applied to the wrist extensors of healthy adults, using fNIRS as the primary assessment modality.MethodsIn a ...
Fengyun Yu, Fengyun Yu, Weining Wang, Leyi Xu, Sijie Liang, Ruiping Hu, Yulian Zhu   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Implied motion activation in cortical area MT can be explained by visual low-level features [PDF]

, 2011
To investigate form-related activity inmotion-sensitive cortical areas, we recorded cell responses to animate implied motion in macaque middle temporal (MT) and medial superior temporal (MST) cortex and investigated these areas using fMRI in humans.
van Wezel, Richard J. A., Nick E. Barraclough, Xiao, Dengke, Perrett, David I., Jacob Duijnhouwer, van Wezel, Richard J.A., Xiao, D.K., Barraclough, Nick E., Barraclough, N., Duijnhouwer, J., Xiao, D., Jeannette A. M. Lorteije, Dengke Xiao, Lorteije, J.A., Mike W. Oram, van Wezel, Richard Jack Anton, Lorteije, Jeannette A. M., Oram, Mike W., David I. Perrett, Duijnhouwer, Jacob, Lorteije, J.A.M., Lorteije, Jeannette A.M., Oram, M.W., Mathijs Raemaekers, Lankheet, Martin J. M., Raemaekers, Mathijs, Jellema, Tjeerd, Richard J. A. van Wezel, Wezel, R.J.A., Lankheet, Martin J.M., Perrett, D.I., Raemaekers, M., Lankheet, M.J.M., Barraclough, N.E., Jellema, T., Martin J. M. Lankheet, Wezel, R.J.A. van, Tjeerd Jellema   +37 more
core   +2 more sources