Results 181 to 190 of about 68,479 (299)

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players. [PDF]

iScience
Yu KC, Wiesman AI, Davenport EM, Flashman LA, Urban JE, Nagarajan SS, Solingpuram Sai KK, Stitzel JD, Maldjian JA, Whitlow CT.   +9 more
europepmc   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Increased cortical excitability to transcranial magnetic stimulation at the brain-tumor interface of <i>IDH1</i>-mutant gliomas. [PDF]

Neurooncol Adv
Stark A, Gorbachuk M, Machetanz K, Leao MT, Liebsch M, Wang S, Honegger J, Tatagiba M, Naros G.   +8 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism. [PDF]

Brain
Vitale C, Jaudon F, Luján R, Bartolucci M, Celora L, Reisoli E, Ruggeri R, Petretto A, Thalhammer A, Cingolani LA.   +9 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Visual Neuroplasticity: Modulating Cortical Excitability with Flickering Light Stimulation. [PDF]

J Imaging
Ávila FJ.
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Cortical excitability and brain function in patients with insomnia: a pilot transcranial magnetic stimulation and functional near-infrared spectroscopy study. [PDF]

Front Neurosci
Luo J, Chen Q.
europepmc   +1 more source