Results 201 to 210 of about 118,658 (298)

Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning

Epilepsia Open, EarlyView.
Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang, Qianqian Zhang, Guangming Li, Lingting Yu, Yanling Ma, Xiaoli Hong, Yujie Kui, Shanshan Cai, Jianguang Sun, Zechao Zhu   +9 more
wiley   +1 more source

Correction: Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation. [PDF]

J Neuroeng Rehabil
Tingting L, Lilin C, Chuangjia W, Jiamen S, Shuxian Z, Yinan A, Hanjun L, Haiqing Z.   +7 more
europepmc   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, EarlyView.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, EarlyView.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability. [PDF]

Elife
Labruna L, Merrick C, Peterchev AV, Inglis B, Ivry RB, Sheltraw D.   +5 more
europepmc   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Cortical excitability and analgesic effects of multisite transcranial direct current stimulation targeting the motor cortex and cerebellum in fibromyalgia. [PDF]

Sci Rep
Betancur DFA, da Graça Lopes Tarragó M, França BR, Bueno GB, Gomes J, Coelho ML, Venturini CL, Torres ILS, Fregni F, Bock H, Caumo W.   +10 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

NDNF+ interneurons have a privileged role in regulating cortical excitability

Richardson A, Mercier MS, Shimoda Y, Graham RT, Leite M, Garcia A, Muller M, Bond SA, Grozdanova M, Wu Q, Lieb A, Kullmann DM, Magloire V.   +12 more
europepmc   +1 more source

Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability. [PDF]

Front Hum Neurosci
Zhao Y, Yan Y, Zhang X, Xie G, Yang R, Zou S, Gao F, Sun W.   +7 more
europepmc   +1 more source