Molecular signatures of cortical expansion in the human foetal brain [PDF]
Nature CommunicationsThe third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this diversity ...
G. Ball +12 more
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Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval [PDF]
Nature CommunicationsHow are past experiences reconstructed from memory? Learning is thought to compress external inputs into low-dimensional hippocampal representations, later expanded into high-dimensional cortical activity during recall.
Casper Kerrén +2 more
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Biomechanical Models and Mechanisms of Cellular Morphogenesis and Cerebral Cortical Expansion and Folding [PDF]
Seminars in Cell and Developmental Biology, 2023 Morphogenesis of the nervous system involves a highly complex spatio-temporal pattern of physical forces (mainly tension and pressure) acting on cells and tissues that are pliable but have an intricately organized cytoskeletal infrastructure. This review begins by covering basic principles of biomechanics and the core cytoskeletal toolkit used to ...
David C. Van Essen
exaly +7 more sources
Familial Adult Myoclonus Epilepsy: A Non-Coding Repeat Expansion Disorder of Cerebellar–Thalamic–Cortical Loop [PDF]
Cells, 2023 Familial adult myoclonus Epilepsy (FAME) is a non-coding repeat expansion disorder that has been reported under different acronyms and initially linked to four main loci: FAME1 (8q23.3–q24.1), FAME 2 (2p11.1–q12.1), FAME3 (5p15.31–p15.1), and FAME4 (3q26.
Claudia Cuccurullo +2 more
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Cross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules [PDF]
Translational PsychiatryPsychedelic drugs exert rapid and profound effects on human consciousness [1–7] and are increasingly being investigated for their therapeutic potential [8–14].
Patrick A. McConnell +8 more
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Longitudinal Magnetic Resonance Imaging Reveals Differences in Cortical Expansion in Fetuses With Congenital Heart Defects [PDF]
Cerebral CortexKara E Garcia
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The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development
Cell Reports, 2021 Summary: Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering early
Min-Yi Ou +6 more
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Journal of Biological Research - Thessaloniki, 2021 Background Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana. While the regulation of cell wall properties by cortical microtubules is well studied, the data on the ...
Veronica Giourieva, Emmanuel Panteris
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Cellular scaling rules for the brain of Artiodactyla include a highly folded cortex with few neurons
Frontiers in Neuroanatomy, 2014 Quantitative analysis of the cellular composition of rodent, primate, insectivore and afrotherian brains has shown that nonneuronal scaling rules are similar across these mammalian orders that diverged about 95 million years ago, and therefore appear to ...
Rodrigo eSiqueira Kazu +4 more
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Frontiers in Neuroanatomy, 2013 How are neurons distributed along the cortical surface and across functional areas? Here we use the isotropic fractionator (Herculano-Houzel and Lent, 2005) to analyze the distribution of neurons across the entire isocortex of the mouse, divided into 18 ...
Suzana eHerculano-Houzel +2 more
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