Results 221 to 230 of about 1,585,655 (272)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Letter to "A New Method for Optimizing Spinal Canal Cross-Sectional Area During Laminoplasty: Lateral Mass Gutter". [PDF]

Global Spine J
Peng C.
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Dissecting Hypoxia Inducible Factor-Driven High Bone Mass Phenotype in Mice Lacking Osteocytic Von Hippel-Lindau. [PDF]

JBMR Plus
Pantoja AP, Mendoza SV, Murugesh DK, Christiansen BA, Loots GG, Genetos DC, Yellowley CE.   +6 more
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Mandibular Cemento-Osseous Dysplasia: A Report of Three Cases in Indian Women With Emphasis on Diagnostic Challenges. [PDF]

Case Rep Dent
Ramalingam S, Rajan ST, Sampath V, Sam S.   +3 more
europepmc   +1 more source

Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion. [PDF]

Dev Cogn Neurosci
Feng J, Jia Q, Wang D, Liu F.
europepmc   +1 more source

Cortical expansion in the development of complex mammalian brain

Opera Medica et Physiologica, 2016
openaire   +1 more source

Trabecular architecture of the medullary cavity: a comprehensive review of radiological patterns, pathological alterations. [PDF]

Br J Radiol
Chapala S, Kiyawat V, Gibson J, Chinniah P, Arora S, Shah A, Vaiyapuri S, Nischal N, Botchu R.   +8 more
europepmc   +1 more source