Estrogen modulation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache trigger. Migraine
Chiho Kudo +4 more
doaj +5 more sources
Cortical spreading depression and meningeal nociception [PDF]
Neurobiology of Pain, 2022 Migraine results in an enormous burden on individuals and societies due to its high prevalence, significant disability, and considerable economic costs.
Simone Carneiro-Nascimento, Dan Levy
doaj +4 more sources
Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms.
Marina Vitale +4 more
doaj +5 more sources
ROS/TRPA1/CGRP signaling mediates cortical spreading depression [PDF]
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +7 more sources
Study on “Atypical” Migraine Auras in the Pediatric Age: The Role of Cortical Spreading Depression and the Physiopathogenetic Hypothesis Arising from Our Clinical Cases [PDF]
Life, 2022 Migraine is a complex neurologic disorder by which several systems of the central nervous system (autonomous system, affective, cognitive, sensory and motor system) may be affected on different levels.
Vincenzo Raieli +5 more
doaj +4 more sources
Diversity of cortical activity changes beyond depression during Spreading Depolarizations [PDF]
Nature Communications, 2023 Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in ...
Azat Nasretdinov +8 more
doaj +2 more sources
Mathematical Psychiatry: On Cortical Spreading Depression—A Review [PDF]
Brain Sciences, 2023 The concept of migraine with aura (MwA) is a widespread condition that can affect up to 30% of migraine patients and manifests itself as a temporary visual illusion followed by a prolonged headache. It was initially pitched as a neurological disease, and
Ejay Nsugbe
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Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping [PDF]
Molecular Brain, 2022 Highlights 1. We established an optogenetic mouse CSD model without irritation dura, which could mimic the behaviors of headache and photophobia. 2. It was the first time to depict a broad, unbiased neuronal activity map throughout the mouse brain after ...
Chenghui Pi +8 more
doaj +2 more sources
Metabolic Pathophysiology of Cortical Spreading Depression: A Review [PDF]
Brain SciencesCortical spreading depression (CSD) is an electrophysiologic pathological state in which a wave of depolarization in the cerebral cortex is followed by the suppression of spontaneous neuronal activity.
Arren Hill +12 more
doaj +2 more sources
Susceptibility Weighted Imaging as a Biomarker for Cortical Spreading Depression [PDF]
Clinical and Translational NeuroscienceIntroduction: Cortical spreading depression (CSD) is thought to be the pathophysiologic correlate of migraine aura. In experimental animals, CSD was shown to cause an increase in oxyhemoglobin.
Adrian Scutelnic +5 more
doaj +2 more sources