Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms.
Marina Vitale +4 more
doaj +6 more sources
Estrogen modulation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache trigger. Migraine
Chiho Kudo +4 more
doaj +5 more sources
Cortical spreading depression and meningeal nociception [PDF]
Neurobiology of Pain, 2022 Migraine results in an enormous burden on individuals and societies due to its high prevalence, significant disability, and considerable economic costs.
Simone Carneiro-Nascimento, Dan Levy
doaj +5 more sources
ROS/TRPA1/CGRP signaling mediates cortical spreading depression [PDF]
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +8 more sources
Neuroprotection and acidosis induced by cortical spreading depression [PDF]
Neuropsychiatric Disease and Treatment, 2016 Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading ...
Kwong KK, Chan ST
doaj +11 more sources
Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping [PDF]
Molecular Brain, 2022 Highlights 1. We established an optogenetic mouse CSD model without irritation dura, which could mimic the behaviors of headache and photophobia. 2. It was the first time to depict a broad, unbiased neuronal activity map throughout the mouse brain after ...
Chenghui Pi +8 more
doaj +3 more sources
Cortical spreading depression induces propagating activation of the thalamus ventral posteromedial nucleus in awake mice [PDF]
The Journal of Headache and Pain, 2022 Background As the relay centre for processing sensory information, the thalamus may involve in the abnormal sensory procedure caused by cortical spreading depression (CSD).
Xiaoxi Fu +3 more
doaj +3 more sources
Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer's disease. [PDF]
Elife, 2022 Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including ...
Shabir O +11 more
europepmc +3 more sources
Mathematical Psychiatry: On Cortical Spreading Depression—A Review [PDF]
Brain Sciences, 2023 The concept of migraine with aura (MwA) is a widespread condition that can affect up to 30% of migraine patients and manifests itself as a temporary visual illusion followed by a prolonged headache. It was initially pitched as a neurological disease, and
Ejay Nsugbe
doaj +4 more sources
Migrainous Infarction and Cortical Spreading Depression. [PDF]
Discoveries (Craiova), 2020 Migraine is a very common disorder of the nervous system. It shares similar physiological processes with stroke. Migrainous infarction is a rare complication of migraine with aura.
Iftikhar W +3 more
europepmc +4 more sources