Results 101 to 110 of about 30,052 (310)

Neuro-ophthalmology and migraine: visual aura and its neural basis

International Journal of Emergency Medicine
Background Migraine, a chronic neurological condition often accompanied by visual aura, which affects 15–33% of migraineurs, often presents as transient visual disturbances such as scintillating scotoma and teichopsia. These symptoms arise primarily from
Hajar Nasir Tukur, Olivier Uwishema, Dalal Sheikhah, Hatice Akbay   +3 more
doaj   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization

PAIN Reports, 2018
. Introduction:. Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents.
Jun Zhao, Dan Levy
doaj   +1 more source

Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]

, 2012
OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S., Awe, Olatilewa, Elliott, Melanie B., Jallo, Jack I., Oshinsky, Michael L.   +4 more
core   +2 more sources

Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures

Annals of Neurology, EarlyView.
We report the first human use of intranasal seletracetam (SEL) to prevent reflex seizures. A patient with epilepsy with reading‐induced seizures on levetiracetam (3,000 mg/day) continued to experience reading‐induced focal seizures with preserved consciousness.
Matthias J. Koepp, Kai‐Nicolas Poppert, Thomas Felder, Aljoscha Thomschewski, Sandra Lafenthaler, Pavel Klein, Alexander Rotenberg, Wolfgang Löscher, Chris Rundfeldt, Eugen Trinka   +9 more
wiley   +1 more source

Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model

Neuroscience Research
One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature.
Eiji Kitamura, Naomi Kanazawa, Takahiro Iizuka, Kazutoshi Nishiyama   +3 more
doaj   +1 more source

Familial Hemiplegic Migraine with Prolonged Coma and Hyperthermia: ATP1A2 Gene Mutation Case Report in a Single Saudi Family.

Journal of Biochemical and Clinical Genetics, 2019
Background: Familial hemiplegic migraine (FHM) is a rare disorder presented commonly with coma, hyperthermia, and headache. FHM is usually associated with fully reversible motor weakness as a specific symptom of aura.
Waleed Altwaijri, Fuad Almalki, Ahmed Al-Rumayyan, Safiyyah Asiri   +3 more
doaj   +1 more source

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. [PDF]

, 2016
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development ...
Ayata, C., Dreier, JP., Fabricius, M., Farkas, Eszter, Sakowitz, OW., Shuttleworth C., William   +5 more
core   +1 more source

Cortical spreading depression and habituation [PDF]

Psychonomic Science, 1966
Habituation of exploratory activity in a novel situation was studied in rats under several conditions of cortical spreading depression. The results suggest the tentative conclusion that the cortex is not necessary for temporary storage of information pertaining to the stimulus situation, but is needed for permanent storage of this same information.
openaire   +1 more source

A mathematical model for spreading cortical depression

Biophysical Journal, 1978
A mathematical model is derived from physiological considerations for slow potential waves (called spreading depression) in cortical neuronal structures. The variables taken into account are the intra- and extracellular concentrations of Na+, Cl-, K+, and Ca++, together with excitatory and inhibitor transmitter substances.
Tuckwell, H.C., Miura, R.M.
openaire   +2 more sources