Results 101 to 110 of about 53,540 (338)

A hypothetical proposal for association between migraine and Meniere's disease. [PDF]

, 2020
Meniere's disease (MD) is a chronic condition affecting the inner ear whose precise etiology is currently unknown. We propose the hypothesis that MD is a migraine-related phenomenon which may have implications for future treatment options for both ...
Abouzari, Mehdi, Djalilian, Hamid R, Lin, Harrison W, Sarna, Brooke   +3 more
core  

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats

Cephalalgia, 2019
Background Botulinum neurotoxin type A, an FDA-approved prophylactic drug for chronic migraine, is thought to achieve its therapeutic effect through blocking activation of unmyelinated meningeal nociceptors and their downstream communications with ...
A. Melo-Carrillo, A. Strassman, Aaron J. Schain, R. Noseda, S. Ashina, A. Adams, M. Brin, R. Burstein   +7 more
semanticscholar   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

A Multidomain Model for Ionic Electrodiffusion and Osmosis with an Application to Cortical Spreading Depression [PDF]

, 2014
Ionic electrodiffusion and osmotic water flow are central processes in many physiological systems. We formulate a system of partial differential equations that governs ion movement and water flow in biological tissue.
Mori, Yoichiro
core  

Memantine for prevention of migraine: a retrospective study of 60 cases. [PDF]

, 2007
The objective was to retrospectively characterise the efficacy of memantine as preventive therapy in a series of patients with frequent migraine. Patients in a university headache clinic completed a survey regarding their experience with memantine, and ...
Brennan, Kevin C, Charles, Andrew, Flippen, Charles, Romero Reyes, Marcela   +3 more
core   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Familial Hemiplegic Migraine with Prolonged Coma and Hyperthermia: ATP1A2 Gene Mutation Case Report in a Single Saudi Family.

Journal of Biochemical and Clinical Genetics, 2019
Background: Familial hemiplegic migraine (FHM) is a rare disorder presented commonly with coma, hyperthermia, and headache. FHM is usually associated with fully reversible motor weakness as a specific symptom of aura.
Waleed Altwaijri, Fuad Almalki, Ahmed Al-Rumayyan, Safiyyah Asiri   +3 more
doaj   +1 more source

Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs

, 2014
The classical Hodgkin--Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied by the ...
Dahlem, Markus A., Hübel, Niklas
core   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, EarlyView.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source