Results 91 to 100 of about 64,639 (211)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, Volume 183, Issue 23, Page 6824-6846, December 2026.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Corticospinal and intracortical excitability of the quadriceps in patients with knee osteoarthritis [PDF]

Experimental Brain Research, 2014
Deficits in voluntary activation of the quadriceps muscle are characteristic of knee osteoarthritis (OA), contributing to the quadriceps weakness that is also a hallmark of the disease. The mechanisms underlying this central activation deficit (CAD) are unknown, although cortical mechanisms may be involved.
Andrew J, Kittelson, Abbey C, Thomas, Benzi M, Kluger, Jennifer E, Stevens-Lapsley   +3 more
openaire   +2 more sources

Transcranial Pulse Stimulation in Parkinson's Disease: A Systematic Review

Brain and Behavior, Volume 16, Issue 11, November 2026.
Transcranial pulse stimulation (TPS) may modulate sensorimotor networks in Parkinson's disease and improve selected outcomes, particularly manual dexterity and short‐term resting tremor. However, the certainty of evidence ranges from moderate to very low, and current evidence is insufficient to establish routine clinical efficacy.
Gabrielly Santos Pereira, Gustavo Henrique de Mello Rosa, Palmerindo Antônio Tavares de Mendonça Neto, João Eduardo de Araújo, Marcelo Lourenço da Silva   +4 more
wiley   +1 more source

Strength Training with Superimposed Whole Body Vibration Does Not Preferentially Modulate Cortical Plasticity

The Scientific World Journal, 2012
Paired-pulse transcranial magnetic stimulation (TMS) was used to investigate 4 wks of leg strength training with and without whole body vibration (WBV) on corticospinal excitability and short-latency intracortical inhibition (SICI).
Ashleigh T. Weier, Dawson J. Kidgell
doaj   +1 more source

Functional Assessment of Corticospinal System Excitability in Karate Athletes

PLOS ONE, 2016
To investigate the involvement of the primary motor cortex (M1) in the coordination performance of karate athletes through transcranial magnetic stimulation (TMS).Thirteen right-handed male karate athletes (25.0±5.0 years) and 13 matched non-athlete controls (26.7±6.2 years) were enrolled.
Moscatelli, Fiorenzo, Messina, Giovanni, Valenzano, Anna, Monda, Vincenzo, VIGGIANO, Andrea, Messina, Antonietta, Petito, Annamaria, Triggiani, Antonio Ivano, Ciliberti, Michela Anna Pia, MONDA, Marcellino, Capranica, Laura, CIBELLI, giuseppe   +11 more
openaire   +6 more sources

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3534-3545, October 2026.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability.

PLoS ONE, 2019
Transcranial direct current stimulation (tDCS) and peripheral nerve electrical stimulation (PES) can change corticospinal excitability. tDCS can be used to non-invasively modulate the cerebral cortex's excitability by applying weak current to an ...
Shota Tsuiki, Ryoki Sasaki, Shota Miyaguchi, Sho Kojima, Kei Saito, Yasuto Inukai, Mitsuhiro Masaki, Naofumi Otsuru, Hideaki Onishi   +8 more
doaj   +1 more source

Blood Flow Restriction Training in Stroke Rehabilitation: A Narrative Review of Current Evidence and Future Directions

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Post‐stroke motor deficits cause disability, while paresis and comorbidities may limit high‐intensity training. Blood flow restriction training (BFRT) combines low‐intensity exercise with partial vascular occlusion and may promote neuromuscular adaptations at low loads.
Jiawei Tong, Lei Song, Juan Jin, Fangfang Li, Tao Huang, Hang Ying, Jiawei Zhu, Jue Wang, Jie Zhuang   +8 more
wiley   +1 more source

Phase- and workload-dependent changes in corticospinal excitability to the biceps and triceps brachii during arm cycling [PDF]

, 2017
Transcranial magnetic stimulation of the motor cortex and transmastoid electrical stimulation of the corticospinal tract can be used to assess changes in supraspinal and spinal excitability, respectively.
Spence, Alyssa-Joy
core   +1 more source

Diagnosis of an Arachnoid Cyst in a Patient Presenting With Uncommon Depressive Symptoms: Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Arachnoid cysts are most commonly asymptomatic and usually do not need any active treatment. Currently, psychiatric symptoms are seldom taken into consideration during treatment evaluations in this patient population. We present this case of a young man who was treated in our hospital for signs of depression.
Ruth Arias‐Hidalgo, Felipe Ortuño, Sergio Manuel Solís‐Barquero, Maria Fernández‐Seara, Reyes García de Eulate, Aziz Yarkin   +5 more
wiley   +1 more source