Results 91 to 100 of about 334,842 (343)

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Corticosteroid implants for chronic non-infectious uveitis. [PDF]

, 2016
BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid).
Brady, Christopher J, Garg, Sunir J., Law, Hua Andrew, Rahimy, Ehsan, Reddy, Rahul, Sieving, Pamela C., Tang, Johnny, Villanti, Andrea C   +7 more
core   +2 more sources

Adiponectin Assists Thrombopoietic Agents in ITP Treatment by Enhancing Myosin‐9/Rab6A‐Mediated Trafficking of c‐Mpl in MKs

Advanced Science, EarlyView.
This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao, Huixian Ma, Guosheng Li, Jilong Xiao, Zhiyu Shi, Mingying Li, Xinguang Liu, Tao Sun, Chunyan Ji   +8 more
wiley   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial [PDF]

, 2011
<b>Background</b> The immune modulating properties of statins may benefit smokers with asthma. We tested the hypothesis that short-term treatment with atorvastatin improves lung function or indices of asthma control in smokers with asthma.<
A McKay, AA Zeki, AA Zeki, AP Greening, C Joukhadar, Charles McSharry, Christopher J Weir, D Cockcroft, D Menzies, DC Cowan, DW McCarey, E Hothersall, E Juniper, E Juniper, E Juniper, EF Juniper, EF Juniper, EF Juniper, EJ Hothersall, Frances Mair, Georgina Braganza, GW Chalmers, I Pavord, Iona Donnelly, J Greenwood, J-H Lee, Jane Lafferty, JEM Tomlinson, JL Wright, K Ito, K Maneechotesuwan, K Samson, KY Chan, L McKinley, Lisa Jolly, M Castro, M Spears, Mark Spears, MD Eisner, N Santanello, N Takeda, N Thomson, Neil C Thomson, PD N'Guessan, R Chaudhuri, Rekha Chaudhuri, S Janda, S Takahashi, S-E Dahlen, SE Alexeeff, Suzanne M Lloyd, V Siroux, X Ou, X Zhang   +53 more
core   +4 more sources

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Serum cortisol level in indian patients with severe sepsis/septic shock

Journal of Emergencies, Trauma and Shock, 2017
Background: The relationship between cortisol level and sepsis is not known in Indian patients of severe sepsis/septic shock. Aims: The study was done to determine the optimal range of cortisol levels, defining the adrenocortical response, and predicting
Ragavendra Suresh, Naveet Wig, Prasan Kumar Panda, V P Jyotsna, P K Chaturvedi, R M Pandey   +5 more
doaj   +1 more source

A study of the pulmonary complications of preterm infants after prenatal corticosteroids prophylaxis in a major Bulgarian hospital [PDF]

, 2019
: An increasingly common problem in obstetrics and neonatology is premature birth. This problem is the cause of many health complications in premature neonates and is leading to neonatal mortality.
Buttigieg, George G., Mihaylova, Anna, Uchikov, Petar, Uchikova, Ekaterina   +3 more
core  

Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care [PDF]

, 2013
Acknowledgements We thank Robin Taylor for his informative thinking and publications on FeNO, which have helped to influence and direct the thinking of the authors.
A Fuhlbrigge, A Zacharasiewicz, AD Smith, AD Smith, AD Smith, AF Gelb, American Thoracic Society / European Respiratory Society, C Delgado-Corcoran, CE Brightling, CE Brightling, D Lester, D Price, DE Shaw, DE Shaw, DN Payne, E Pizzichini, E Rosi, ED Bateman, ES Koster, G Stern, GL Piacentini, Global Initiative for Asthma, H Powell, HL Petsky, HL Petsky, I Horvath, ID Pavord, J Douwes, J Schilling, JF Donohue, JM Beck-Ripp, KW McGrath, L Grönke, L Wang, M Berry, MG Cochrane, MG Persson, MW Pijnenburg, N Pearce, NHLBI/WHO Workshop Report, P Haldar, P Haldar, RA Dweik, RA Robbins, RH Green, RH Green, RJ Green, RS Zeiger, SA Kharitonov, SJ Langley, ST Yavuz, TA Mahr, TL Frank, WJ Calhoun   +53 more
core   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source