Results 111 to 120 of about 516,590 (413)
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans [PDF]
arXiv, 2023 Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame insertion of 12 base pairs coding for Lys, Cys, Ser, Trp (KCSW) in their DNA-binding domain (DBD) and the presence of two amino acid mutations in their amino terminal domain (NTD).
arxiv
Journal of Managed Care & Specialty Pharmacy, 2016 BACKGROUND: Systemic corticosteroids are a leading cause of drug-related complications, yet little has been done to quantify the dose-response relationship between systemic corticosteroid exposure and complications in patients with severe asthma ...
Anand A. Dalal +9 more
semanticscholar +1 more source
Complications of percutaneous endoscopic gastrostomy in dogs and cats receiving corticosteroid treatment [PDF]
, 2016 BACKGROUND: Corticosteroid treatment is commonly required in veterinary patients for treatment of inflammatory, immune‐mediated, neurologic, and neoplastic diseases, which also may require assisted enteral nutrition via percutaneous endoscopic ...
Aguiar, J, Chang, Y M, Garden, O A
core +1 more source
Advanced Science, EarlyView.Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová +27 more
wiley +1 more source
Older patients with COVID‐19 and neuropsychiatric conditions: A study of risk factors for mortality
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Little is known about risk factors for mortality in older patients with COVID‐19 and neuropsychiatric conditions. Methods We conducted a multicentric retrospective observational study at Assistance Publique‐Hôpitaux de Paris. We selected inpatients aged 70 years or older, with COVID‐19 and preexisting neuropsychiatric comorbidities
Vi‐Huong Nguyen‐Michel +23 more
wiley +1 more source
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor [PDF]
arXiv, 2020 The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of progesterone is its high affinity for the mineralocorticoid receptor (MR), which regulates electrolyte ...
arxiv
Critical Care, 2016 BackgroundPatients with 2009 pandemic influenza A(H1N1pdm09)-related critical illness were frequently treated with systemic corticosteroids. While observational studies have reported significant corticosteroid-associated mortality after adjusting for ...
Jesse W. Delaney +16 more
semanticscholar +1 more source
Comparative Effectiveness of Step-up Therapies in Children with Asthma Prescribed Inhaled Corticosteroids : A Historical Cohort Study [PDF]
, 2017 This work was supported by the Respiratory Effectiveness Group. Acknowledgments We thank the Respiratory Effectiveness Group for funding this work, Annie Burden for assistance with statistics, and Simon Van Rysewyk and Lisa Law for assistance with ...
Murray, Claire S. +4 more
core +1 more source
Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas
Advanced Science, EarlyView.Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang +18 more
wiley +1 more source