Results 111 to 120 of about 342,940 (312)
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Do corticosteroids affect immunotherapy efficacy in malignancy? – A systematic review
Background Early studies indicated that corticosteroids may limit the survival benefit from immunotherapy. We conducted this systematic review to evaluate the effect corticosteroids have on immunotherapy in patients with malignancy, when adjusted for ...
Byron, Y, Yegorova-Lee, S, Tio, M
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Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH). [PDF]
, 2014 INTRODUCTION: Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine use but whether it improves outcome remains uncertain.
Brett, Stephen J. +13 more
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Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Advanced Science, EarlyView.Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
Antenatal corticosteroids [PDF]
Canadian Medical Association Journal, 2017 Julia, Kfouri, Rohan, D'Souza
openaire +5 more sources
The Use of High-dose Corticosteroids in Seriously Ill Children with Acute Viral Bronchiolitis
, 2020 Introduction:The aim of the present study is to investigate whether high-dose corticosteroids cause a clinical improvement in seriously ill children with acute viral bronchiolitis.Methods:Hospital records of patients diagnosed with acute viral ...
Çelebi Kocaoğlu
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Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
Optic neuritis as an early sign of multiple sclerosis
Eye and Brain, 2016 Nilufer Kale Department of Neurology, Bakirkoy Prof Dr Mazhar Osman Training and Research Hospital, Istanbul, Turkey Abstract: Optic neuritis (ON) is an acute inflammatory demyelinating disorder of the optic nerve. The general characteristics of isolated
Kale N
doaj
PharmaceuticalsBackground/Objectives: Enfortumab vedotin (EV) is an antibody-drug conjugate (ADC) that combines monomethyl auristatin E (MMAE), a potent cytotoxic agent, with a monoclonal antibody targeting Nectin-4. It has emerged as a promising therapy for metastatic
Grégoire Desimpel +4 more
doaj +1 more source
Corticosteroids in pediatric endocrinology
, 2015 This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries.
GIANNINI, COSIMO, MOHN, Angelika Anna
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