Results 141 to 150 of about 469,630 (315)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Systemic corticosteroids for acute sinusitis [PDF]

, 2014
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Rovers, Maroeska M., Thompson, Matthew J., Venekamp, Roderick P.   +7 more
core   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Long‐Term Outcomes After Stoma Creation in Crohn's Disease: A Retrospective Cohort Study of 422 Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Stoma creation is often required in Crohn's disease (CD), most commonly because of progressive anorectal disease. As stoma closure strongly influences long‐term quality of life and surgical decision‐making, this study evaluated the indications and long‐term outcomes of stoma creation in patients with CD.
Kentaro Nagano, Ryuichi Kuwahara, Yusuke Tomoo, Kurando Kusunoki, Yuki Horio, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Motoi Uchino, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double‐Blinded, Placebo‐Controlled, Phase 3 Trial

American Journal of Hematology, EarlyView.
ABSTRACT Primary autoimmune thrombocytopenia (ITP) is characterized by thrombocytopenia, bleeding, and reduced health‐related quality of life. In the Phase 3 ADVANCE IV study, intravenous efgartigimod induced significant platelet count responses versus placebo in patients with chronic ITP. ADVANCE SC, a Phase 3, multicenter, randomized, double‐blinded,
Nichola Cooper, Catherine M. Broome, Yoshitaka Miyakawa, Vickie McDonald, Hanny Al‐Samkari, Abderrahim Khelif, Spero R. Cataland, Wilma Barcellini, Renchi Yang, Heng Mei, Filip Matthijssens, Anna Hultberg, Giorgia Ciurlia, Domenica Gandini, Jaume Ayguasanosa, Kristof De Beuf, Ségolène Pastouret, Waleed Ghanima, Francesco Rodeghiero, James B. Bussel, the ADVANCE SC Investigator Trial Group, Marcela Sarmiento, Anahi Rollheiser, Hugo Ferro, Victoria Caula, Edgardo Garcia Espina, Sebastian Pastoriza, Ross I Baker, Maan Alwan, Peter Thian Guan Tan, Jir‐Ping Boey, Jack Karel Driml, Jennifer Curnow, Emily Blyth, Taryn Freeman, Amanda Johnston, John Kwan, Chun Ma, Jonathan Marwick, Kenneth Micklethwaite, Lachlin Vaughan, Zane Kaplan, Gareth Gregory, Emma Leitinger, Christopher Leow, Alexandra Murton, Jeremy Ong, Ross Salvaris, Maciej Jan Tatarczuch, Jonathan Wong, Ahmad Zargari, Michael Leahy, Philip Young‐Ill Choi, Angeline Audrey Achola Josiah, Kisoth Arasaratnam, Fathima Ayyalil, Samuel Bennett, Philip Crispin, James D’Rozario, Melanie D’Souza, Thomas Gleeson, Maya Latimer, Edwin Lee, Jun Lim, Ross Lindell‐Innes, Mridula Mokoonlall, Jun Ng, Nalini Pati, Michael Pidcock, Kristy Natasha Rady, Caitllin Thirunavukarasu, Pencho Georgiev, Maria Dimitrova, Zhanet Grudeva‐Popova, Bulent Nihat, Alexander M. Arellano Rojas, Christine M. Rojas Hopkins, Eugenia Loredo Fort, Eduardo P. Yáñez Ruiz, Mauro Leandro Morales Sanhueza, Patricio Yanez Weber, Renchi Yang, Yunfei Chen, Ting Sun, Yun Zhuang, Lei Yang, Feng Zhang, Jiajia Li, Jun Li, Lin Liu, Meng Wang, Yanli Yang, Fangbing Zhu, Junfeng Zhu, Heng Mei, Danying Liao, Quizhe Wei, Hu Zhou, Bingjie Ding, Mengjuan Li, Xuewen Song, Lina Zhang, Yuanyuan Zhang, Liang Wang, Jia Cong, Liqiang Wei, Na Yao, Hongyu Zhang, Silang Chen, Jia Feng, Lihua Sun, Haichan Xu, Lei Xu, Qian Zhang, Fengluan Zhong, Guo wei Li, Guoshu Chen, Li Chen, Xiaoyu Chen, Dongting Liu, Xiaohua Qin, Xiaoling Xie, Xiaoming Fei, D. Wenping Lu, Yilong Lu, Ming Luo, Lixia Wang, Xianqiu Yu, Xin Wang, Chao Ding, Xiaoqiong Duan, Wenhua He, Liping Huan, Yanqiu Li, Juan Liu, Ningning Tang, Wei Yin, Mamia Zodelva, Irine Datikashvili‐David, Nino Sharashenidze, Levan Makhaldiani, Teano Gamezardashvili, Ekaterine Gaprindashvili, Tamar Gersamia, Magdana Betaneli, Tamta Makharadze, Anargyros Symeonidis, Maria‐Lamprini Kasti, Alexandra Kourakli, Vasileios Lazaris, Andi Prekazi, Angelos Sarantopoulos, Marina Mantzourani, Vasiliki Antoniadou, Dimitra Vlachopoulou, Antonia Syrigou, Achilles Anagnostopoulos, Eleni Gavriilaki, Michail Iskas, Ioanna Sakellari, Christos Varelas, Ronan G. Desmond, Paraic Behan, Helen Enright, Christopher Fox, John McHugh, Grace Rothwell‐Kelly, Louisa Shackleton, Ilana Levy‐Yurkovski, Natalia Kreiniz, Sarah Matarasso‐Greenfeld, Tamar Tadmor, Anatoly Nemets, Alexander Avroutine, Yosef Barshay, Tatiana Boulygin, Shirley Zafrir‐Haver, Andrea Patriarca, Riccardo Moia, Maura Nocolosi, Wilma Barcellini, Bruno Fattizzo, Juri Giannotta, Felicetto Ferrara, Barbara Pocali, Antonio Cuneo, Maurizio Cavallari, Francesco Cavazzini, Maria Ciccone, Gian Matteo, Mariarosaria Sessa, Paolo Tomasi, Antonio Urso, Fabrizio Pane, Federico Chiurazzi, Giada Muccioli Casadei, Alessandro Lucchesi, Maria Giannini, Giovanni Marconi, Giorgia Micucci, Marianna Norata, Monica Poggiaspalla, Elena Rossi, Valerio De Stefano, Tomoki Ito, Shinya Fujita, Masaaki Hotta, Akiko Konishi, Takahisa Nakanishi, Atsushi Satake, Hideaki Yoshimura, Akio Saito, Naoki Akashi, Hirono Iriuchishima, Akira Matsumoto, Morio Matsumoto, Masahiro Mihara, Keita Nakayama, Morio Sawamura, Yukie Terasaki, Yoshitaka Miyakawa, Ryohei Abe, Atsushi Ohsaki, Kohei Saito, Rie Shiomi, Kodai Suzuki, Kento Umino, Shoko Ito, Masahiro Ashiwaza, Shinichiro Fujiwara, Kaoru Morita, Yoshinobu Kanda, Daisuke Minakata, Rui Murahashi, Hirotomo Nakashima, Ken Ohmine, Tsukasa Ohmori, Kazuya Sato, Yumiko Toda, Masuzu Ueda, Chihiro Yamamoto, Katsutoshi Ozaki, Yuya Kishida, Yasuko Kuribayashi, Keita Kirito, Eriko Hosokawa, Hideto Hyuga, Ichiro Kawashima, Megumi Koshiishi, Takuma Kumagai, Minori Matsuura, Kei Nakajima, Yuma Sakamotot, Masaru Tanaka, Takeo Yamamoto, Ryosuke Ogawa, Kenichi Aoki, Kentaro Kohno, Akihiko Numata, Teppei Obara, Yotaro Tamai, Wataru Kamata, Teiko Kawahigashi, Shuku Sato, Shun Tsunado, Shigeki Ito, Shugo Kowata, Tatsuo Oyake, Suleimman Al‐Sweedan, Dalia Alsweedan, Raghad Irshaid, Nour Sameeh, Muath Thiabat, Abdalla Awidi Abbadi, Feras Al Fararjeh, Alaa Alshorman, Jong‐Ho Won, Kyoung Ha Kim, Seug Yun Yoon, Soo‐Mee Bang, Sang‐A Kim, Jeong‐Ok Lee, Ji Yun Lee, June‐Won Cheong, Ji Eun Jang, Hyun Soo Cho, Haerim Chung, Doh Yu Hwang, Yu Ri Kim, Hyewon Kook, Yunsuk Choi, Kyoo‐Hyung Lee, Eun‐Ji Choi, Je‐Hwan Lee, Jung‐Hee Lee, Hang‐Seung Park, Mariela Cardiel Silva, Ivan Gamez Valdez, Karen Miranda Fernandez, Carlos Chavez Trillo, Alva Zaragoza Vazquez, Marco A. Velasco Rojas, Ximena Arenas Reyes, Jessica Graciela Reyes Contreras, Francisco Hernandez Rodriguez, Kirsty Marshall, Sharon Jackson, Amy J. Holmes, Peter Ganly, Andrew Butler, Wei‐Hsun Hsu, Sean Macpherson, Emma‐Jane McDonald, Wendy Stewart, Waleed Ghanima, Eiriki Tjonnfjord, Sebastian Grosicki, Ewa Bodzenta, Marek Kriegler, Zofia Spyra‐Gorny, Maria Soroka‐Wojtaszko, Oliwia Bachanek‐Mitura, Justyna Kozinska, Szymon Fornagiel, Beata Kumiega, Grzegorz Basak, Jagoda Rytel, Maciej Kazmierczak, Piotr Cieslak, Emil Durka, Marek Kotlarski, Michal Kwiatek, Justyna Pieronkiewicz, Lukasz Pruchniewski, Teresa Melo, Mafalda Alpoim, Margarida Badoir, Henrique Coelho, Cristina Fereira, Marta Nunes, Sofie Ramalheira, Antonio Medina de Almeida, Paulo Bernardo, Paula Braga, Maria Fátima Ferreira, Pedro Afonso Costa Baptista, Marta Henriques, Celina Afonso, Guadalupe Gomes, Francisca Miranda, Filipa Mousinho, Ana Ramalhal Jorge, Mariana Vasilica, Andra Tomescu, Luminita Ocroteala, Gabriela Diana Baluta, Doriana Duta, Ioan Macarie, Marcela Candea, Georgeta Daniela Georgescu, Lidia Mihai, Florina Patrinoiu, Alina Catana, Alice Dumitrescu, Gabriela Borsaru, Anca Ciobanu, Laura Cristina Predescu, Delia‐Monica Dima, Ana Maria Bancos, Daniela Dragancea, Simona Galdean, Nicoleta Negru, Sergey Zakharov, Yulia Dubinina, Alvetina Lidzhieva, Uruzmag Tomaev, I Pospelova Tatiana, Tatiana Babaeva, Olga Seregina, Svetlana A. Volkova, Elena Kiseleva, Valeria Turetskova, Maria Novikova, Zhanna Davydova, Irina Novokreschenova, Svetlana Valerievna Samarina, Marina Kokoreva, Zorica Cvetkovic, Tamara Bibic, Milica Tanasjievic, Andrew B. McDonald, David Brittain, Philippa Ashmore, Karen Gunther, Johnny Mahlangu, Ching Yu Wang, Vernon Johan Louw, Cecile Du Toit, Elzanne Jansen van Rensburg, Gerdlen Johanna Kritzinger, Perry Loebenberg, Gamuchirai Tadzimirwa, Estelle Verburgh, Blanca Sanchez Gonzalez, Sara Garcia Avila, Yao‐yu Hsieh, Yu‐Sheng Chang, Tsu‐Yi Chao, Wei‐Hong Cheng, Po‐Ya Chuang, Sheng‐Hong Lin, Hui‐Wen Liu, Archrob Khuhapinant, Rarinee Rungjirajittranon, Noppacharn Uaprasert, Chatphatai Moonla, Suporn Chuncharunee, Pichika Chantrathammachart, Teeraya Puavilai, Chatree Chai‐Adisaksopha, Pokpong Piriyakhuntorn, Tontanai Numbenjapon, Wittawat Jandamnernpong, Rattapan Lamool, Nonglak Kanitsap, Lantarima Bhoopat, Nattiya Teawtrakul, Kanchana Chansung, Theerin Lanamtieng, Chinadol Wanitpongpun, Abderrahim Khelif, Bechir Achour, Walid Bouteraa, Raihane Ben Lakhal, Yosr Abdnnebi, Dorra Dhaouadi, Emna Maaloul, Moez Elloumi, Moez Medhaffa, Selami Kocak Toprak, Bulent Karakaya, Ekin Kircali, Gul Yavuz, Filiz Vural, Nigar Abdullayeva, Aysenur Arslan, Ajda Gunes, Fatma Keklik Karadag, Tural Pashayev, Denis Sabriye Bozer, Bahar Sevgili, Nur Soyer, Tuba Hacibekiroglu, Yasin Kalpakci, Cenk Sunu, Fevzi Altuntas, Semih Basci, Merih Kizil Cakar, Sema Secilmis, Mehmet Sinan Dal, Bahar Uncu Ulu, Samet Yaman, Tugce Nur Yigenoglu, Anil Tombak, Fatma Akbas, Meliha Nalcaci, Simge Erdem, Dilek Ozden Kubilay, Tarik Tiryaki, Ozgur Mehtap, Ayfer Geduk, Meltem Ayli, Tuba Bulduk, Alparslan Merdin, Melda Ozkan, Selim Sayin, Bilge Ugur, Murat Yildirim, Ahmet Muzaffer Demir, Ufuk Demirici, Elif Umit, Ahmet Yigitbasi, Burhan Turgut, Seval Akpinar, Mehmet Sonmez, Ozlen Bektas, Nergiz Erkut, Benjamin Bailiff, Salama Abosaod, Rabia Afghan, Amy Gudger, Tsan Hei Luk, Timothy Moorby, Maria Mushkbar, Beena Salhan, Elizabeth Tebbet, Adam Forbes, Michale Creagh, Nicole Fowler, Michelle Furtado, Cristina Maria Thiebaud Alvarez, David Tucker, Martha Vickers, Nichola Cooper, Christine Ademokun, Nehal Joshi, Lucy Kamuriwo, Clare Rees, Steven Lentz, Mark Karwal, Usha Perepu, Grerk Sutamtewagul, Catherine M. Broome, Pedro Alcedo, Julia Cunningham, Graig Kessler, Sunil Babu, Farrukh Adhami, Carrie Boots, Shalini Chitneni, Ryan Gonzales, Yasolatha Nalamolu, Sreenivasa Nattam, Guinevere Nilles, Ahad Sadiq, Shelley Seabolt, David Zimmerman, Bashar Alasad, Loralei Floden, Samer Hassan, Nasser Janbay, Kellie Larsen‐Dyer, Eric S. Schaefer, Joseph Beck, Daniel Bradford, Brooke Brander, Lynsay Brautnick, Mikaila Calcagni, K’Anne Cash‐Arthur, Rita Draggs, Diane Glendinning, Cristina Hernandez, Sarah Jewell, Matthew Lockwood, Gregory Oakhill, Stephan Rosenfeld, Patrick Travis   +546 more
wiley   +1 more source

Modulation of the effectiveness of 17-alpha-hydroxy-20-beta-dihydroprogesterone or of a gonadotrophic extract on the in vitro intrafollicular maturation of oocytes of the rainbow trout Salmo gairdnerii by various non-maturing steroids [Translation from: Compte Rendu Hebdomadaire des Seances de l'Academie des Sciences, Paris, Series D 281, 811-814, 1975] [PDF]

, 1980
The effectiveness of 17 α-hydroxy-20 β-dihydroprogesterone (17 α-20 β Pg) or of a trout hypophyseal gonadotrophic extract on the in vitro intrafollicular maturation of trout oocytes can be modulated by steroids which do not have a direct maturing effect;
Jalabert, B.
core  

Safety and Effectiveness of Sutimlimab in Cold Agglutinin Disease: A Real‐World International Experience

American Journal of Hematology, EarlyView.
ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo, Elisa Sambruna, Yoshitaka Miyakawa, Marc Michel, Carlo Visco, Michael Fillitz, George Kannourakis, Maria Bruna Greve, Moritz Kleemiss, Johan Cid, Andrea Patriarca, Laura Pavan, Arbana Dizdari, Nilla Maschio, Antonella Sau, Cinzia Bitetti, Riccardo Mario Colombo, Luigi Curreli, Dorela Lame, Uros Markovic, Fabrizio Pappagallo, Giacinto Luca Pedone, Davide Rapezzi, Vincenzo Sammartano, Nicola Tumedei, Antonio Giovanni Solimando, Jalink Marit, Luana Fianchi, Jahanzaib Khwaja, Antonio De Vivo, Francesco Lanza, Fabrizio Vianello, Esther N. Oliva, Catherine Broome, Francesco Passamonti, Ulrich Jaeger, Bernd Jilma, Guillaume Moulis, Wilma Barcellini   +38 more
wiley   +1 more source

Late Cytomegalovirus Infections After Allogeneic Hematopoietic Cell Transplant

American Journal of Hematology, EarlyView.
ABSTRACT Graft versus host disease (GVHD) prophylaxis with posttransplant cyclophosphamide (ptCY) and cytomegalovirus (CMV) prophylaxis with letermovir have changed the clinical epidemiology of CMV infection. We studied the incidence, risk factors for, and outcomes of CMV infection after Day + 90 of allogeneic hematopoietic cell transplant (alloHCT ...
George L. Chen, Roland Bassett, Rohtesh S. Mehta, Betul Oran, Fareed Khawaja, Ella J. Ariza‐Heredia, Yosra Aljawai, Amanda Olson, May Daher, Portia Smallbone, Katayoun Rezvani, Partow Kebriaei, Uday Popat, Richard Champlin, Roy F. Chemaly, Elizabeth J. Shpall   +15 more
wiley   +1 more source