Results 181 to 190 of about 484,106 (362)

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Comparison of Corticosteroid and Sulphasalazine Therapy in Ulcerative Colitis [PDF]

, 1962
S. C. Truelove, G. Watkinson, G J Draper
openalex   +1 more source

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

Clinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj, Dmitry Shchelokov, Oleg Demin Jr, Homer C. Adams 3rd, Yan Feng, Leonid Gibiansky, Saskia van der Lee, Anandhi Johri, Merzu Belete, Alexander Muik, Porntula Panorchan, Özlem Türeci, Uğur Sahin, Tahamtan Ahmadi, Manish Gupta, Oleg Demin, Craig Thalhauser   +16 more
wiley   +1 more source

Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis. [PDF]

, 1967
J. R. Daly, A B Myles, P A Bacon, C G Beardwell, Oswald Savage   +4 more
openalex   +1 more source

Exposure‐Response Relationships for Axatilimab in Patients with Chronic Graft‐Versus‐Host Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Axatilimab, a high‐affinity humanized monoclonal antibody that targets colony‐stimulating factor 1 receptor, is approved for the treatment of chronic graft‐versus‐host disease (cGVHD). Here, we describe the exposure‐response relationships for efficacy and safety in patients with cGVHD who received axatilimab.
Yan‐ou Yang, Alina Volkova, Victor Sokolov, Xing Liu, Cristina Leon, Yuri Kosinsky, Jennifer Sheng, Xuejun Chen   +7 more
wiley   +1 more source

Administration Studies in Equine Antidoping Research: Designing Scientific Investigations to Effectively Direct Medication Control in Racehorses

Drug Testing and Analysis, EarlyView.
ABSTRACT Pharmacokinetics is the study of the movement of drug in the body and includes the processes of absorption, distribution, metabolism, and excretion. Pharmacodynamics is the pharmacologic effect of the drug on the body. The pharmacokinetics of a drug determines its pharmacologic effect. Pharmacokinetic studies describe drug concentrations while
Heather K. Knych
wiley   +1 more source

TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA. V. IN VITRO INHIBITION OF CORTISOL METABOLISM* [PDF]

, 1963
Avery A. Sandberg, W. Roy Slaunwhite
openalex   +1 more source

Sports Supplement Analysis Survey for the Prevalence of WADA Prohibited Substances in the Australian Online Marketplace

Drug Testing and Analysis, EarlyView.
A survey of 200 sports supplements purchased online in Australia and analysed for WADA Prohibited Substances. Athlete education regarding the use of sports supplements remains a high priority as 35% of the products contained WADA Prohibited Substances. ABSTRACT Sports supplements are used extensively by people involved in competitive sports. However, a
Louise Barker, Adam Cawley, Naomi Speers, Kerry Knowler, Karina Chilman   +4 more
wiley   +1 more source

Corticosteroids modulate biofilm formation and virulence of <i>Pseudomonas aeruginosa</i>. [PDF]

Biofilm
Jordana-Lluch E, Escobar-Salom M, Torrens G, Barceló IM, Estévez MÁ, González-Alsina A, Iglesias A, Pont-Antona PJ, Macià MD, Albertí S, Williams P, Cosío BG, Juan C, Oliver A.   +13 more
europepmc   +1 more source

Responses of Adrenal Corticosteroid Secretion to Hypotension and Hypovolemia * [PDF]

, 1965
Donald S. Gann, Richard H. Egdahl
openalex   +1 more source