Machine Learning for Real-World Evidence Analysis of COVID-19 Pharmacotherapy [PDF]
arXiv, 2021 Introduction: Real-world data generated from clinical practice can be used to analyze the real-world evidence (RWE) of COVID-19 pharmacotherapy and validate the results of randomized clinical trials (RCTs). Machine learning (ML) methods are being used in RWE and are promising tools for precision-medicine.
arxiv
Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis. [PDF]
, 2019 BackgroundCoronary artery aneurysms (CAA) are a serious complication of Kawasaki disease. Treatment with intravenous immunoglobulin (IVIg) within 10 days of fever onset reduces the risk of CAA from 25% to <5%.
Baker, Annette L +11 more
core
Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans [PDF]
arXiv, 2023 Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame insertion of 12 base pairs coding for Lys, Cys, Ser, Trp (KCSW) in their DNA-binding domain (DBD) and the presence of two amino acid mutations in their amino terminal domain (NTD).
arxiv
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor [PDF]
arXiv, 2020 The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of progesterone is its high affinity for the mineralocorticoid receptor (MR), which regulates electrolyte ...
arxiv
Corticosteroids in Bell’s Palsy
Pediatric Neurology Briefs, 1999 The effects of corticosteroids on the early and late outcome of 42 children (21 boys, 21 girls) with Bell’s palsy (acute idiopathic facial nerve paralysis) were evaluated in a prospective randomized study at the University of Istanbul, Turkey.
J Gordon Millichap
doaj +1 more source
Reducing neonatal mortality associated with preterm birth: gaps in knowledge of the impact of antenatal corticosteroids on preterm birth outcomes in low-middle income countries [PDF]
, 2016 The Global Network’s Antenatal Corticosteroids Trial (ACT), was a multi-country, cluster-randomized trial to improve appropriate use of antenatal corticosteroids (ACS) in low-resource settings in low-middle income countries (LMIC).
Althabe, Fernando +7 more
core +2 more sources
Guidelines for Corticosteroid use in Treatment of DMD
Pediatric Neurology Briefs, 2016 The guideline development subcommittee of the American Academy of Neurology has provided an update to the 2005 treatment guidelines for use of corticosteroids (CS) in Duchenne muscular dystrophy (DMD).
Vamshi K. Rao
doaj +1 more source
Journal of Dermatology and Dermatologic Surgery, 2020 Pembrolizumab is a humanized monoclonal antibody that targets programmed cell death receptor-1. Stevens–Johnson syndrome (SJS) secondary to pembrolizumab has rarely been described in the treatment of malignant melanoma (MM). A 62-year-old woman developed
Cathal O'Connor +2 more
doaj +1 more source
Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progesterone and Spironolactone [PDF]
arXiv, 2018 We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebrates. Based on their measured activities, aldosterone, cortisol, 11-deoxycorticosterone, corticosterone, 11-deoxcortisol, progesterone and 19 ...
arxiv
The use of inhaled corticosteroids in wheezy pre-school age children : current practice and literature review [PDF]
, 2007 Preschool children and infants frequently suffer wheezy episodes, mostly associated with viral respiratory tract infections. There is no evidence to support the use of maintenance low dose inhaled corticosteroids to prevent or manage episodic mild wheeze
Vella, Cecil
core