Results 121 to 130 of about 48,193 (234)

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

open access: yesMedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen   +11 more
wiley   +1 more source

Memantine Exacerbates Trimethyltin‐Induced Neurodegeneration and Delays Cognitive Impairment Recovery

open access: yesNeuropsychopharmacology Reports, Volume 45, Issue 2, June 2025.
Trimethyltin (TMT) induces transient neuronal loss and cognitive impairments, serving as a model for transient brain damage. This study investigated the effects of early memantine (MEM) treatment on TMT‐induced brain injury. Memantine worsened TMT‐induced cognitive impairment and neuronal degeneration in the hippocampus, suggesting that early MEM ...
Yusuke Onaka   +4 more
wiley   +1 more source

The Presence of a Shelter in an Open Field Test Has Differential Effects on the Behavior and Stress Response of Two Mouse Species

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 343, Issue 4, Page 480-492, May 2025.
ABSTRACT The open field test (OFT) is frequently used in research to assess anxiety‐like behavior and locomotor activity. Its simple design can lead to the misconception that it is a standardized procedure comparable between laboratories. However, some modifications in the setup can cause changes in behavior.
Rita I. Monarca   +4 more
wiley   +1 more source

Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers

open access: yesVeterinary Medicine and Science, Volume 11, Issue 3, May 2025.
This study is the first to report decreased gene expression of brain HSP70 and HSP90 in late embryogenesis of Ross broiler under heat stress, with serotonin serving as an anti‐stress agent by promoting HSP gene expression. ABSTRACT Introduction Broiler chickens are particularly vulnerable to elevated temperatures compared to mammals because they have ...
Hamed KHasti   +4 more
wiley   +1 more source

Gastrointestinal Dysfunction and Low‐Grade Inflammation Associate With Enteric Neuronal Amyloid‐β in a Model for Amyloid Pathology

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 5, May 2025.
Amyloid‐β accumulation in enteric neurons is associated with low‐grade intestinal inflammation, fibrosis, and altered motility in a mouse model for amyloid pathology, suggesting that peripheral pathology may cause gastrointestinal dysfunction in Alzheimer's disease patients. ABSTRACT Background Patients suffering from Alzheimer's disease, a progressive
Kinga Réka Tasnády   +7 more
wiley   +1 more source

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