Results 141 to 150 of about 96,764 (277)

The Protective Effects of Polygala tenuifolia and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments

Foods
Excessive stress is a well-established contributor to neurological damage, insomnia, and depression, imposing a significant burden on individuals and society. This underscores the urgent need for effective stress-relief strategies.
Chaoyi Xue, Zhiyong He, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Fang Qin, Mingmin Chen, Hui Ye, Jie Chen   +8 more
doaj   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

Circadian Corticosterone Profile in Laying Hens (Gallus gallus domesticus)

Animals
Measurement of blood corticosterone concentrations has been established as an indicator for assessment of acute distress. Therefore, knowledge on physiological fluctuations is required, but previous studies allow little conclusion on daily fluctuations ...
Theresa Hillebrecht, Rüdiger Korbel, Monika Rinder, Manfred Gahr   +3 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Abcc1 deficiency protects from corticosterone but not cortisol‐induced adiposity and insulin resistance in a sex‐specific manner

The Journal of Physiology, EarlyView.
Abstract figure legend A mouse model of exogenous glucocorticoid (GC) treatment was used to determine (1) if corticosterone induced the same metabolic dysregulation as cortisol, and (2) whether these differences were mediated by the corticosterone‐specific transmembrane exporter Abcc1.
Mhairi A. Paul, Boglarka Nagy, Sofia Laforest, Joanna P. Simpson, William Mungall, Natalie Z. M. Homer, Robert K. Semple, Ruth Andrew, Roland H. Stimson, Mark Nixon   +9 more
wiley   +1 more source

The impact of pregestational stress on neurodevelopment: Implications for autism spectrum disorder and attention‐deficit/hyperactivity disorder

The Journal of Physiology, EarlyView.
Abstract figure legend Pregestational stress modifies germ‐cell epigenetic information, resulting in GABAergic dysfunction and E/I imbalance in the developing brain, thereby increasing susceptibility to ASD‐and ADHD‐related neurodevelopmental abnormalities in offspring.
Samaneh Ahmadian‐Moghadam, Ehsan Saboory, Shiva Roshan‐Milani   +2 more
wiley   +1 more source

Corticosterone Concentrations in the Mouse [PDF]

Science, 1978
D H, Spackman, V, Riley
openaire   +2 more sources

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, EarlyView.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

Low‐frequency electroacupuncture attenuates insulin resistance in a rat model of diet‐induced maternal obesity

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Introduction Maternal obesity is highly prevalent worldwide, conferring elevated risks of maternal/fetal complications and adult‐onset disease in offspring. Obesity and pregnancy are both states of insulin resistance. Percutaneous electrical stimulation of skeletal muscle, better known as electroacupuncture (EA), mitigates insulin resistance ...
David J. Carr, Elizabeth Kelley, Morgan Sekhon, Megan Kawasaki, Keara McElroy‐Yaggy, R. Chris Skinner, Paul D. Taylor, Anna L. David, Elisabet Stener‐Victorin, Thomas L. Jetton   +9 more
wiley   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley, Tatsuya Sueyoshi, Sivapriya Ramamoorthy, Viktoriya D. Nikolova, David R. Goulding, Jianying Li, Manas K. Ray, Sheryl S. Moy, John A. Cidlowski   +8 more
wiley   +1 more source