Results 151 to 160 of about 96,764 (277)

The Predictive Accuracy of Methods Commonly Used for Evaluating Animal Distress

open access: yesThe FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Predictive accuracy of body weight change, distress score, burrowing, and nesting behavior across multiple intervention phases. ABSTRACT Accurate distress assessment is essential for ensuring animal welfare and scientific validity. Although behavioral and physiological indicators are commonly used, their predictive value across disease models and ...
Emily Leitner   +6 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly   +5 more
wiley   +1 more source

Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography‐Tandem Mass Spectrometry

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Steroids are critical for numerous physiological processes; disruption in their metabolism is associated with numerous endocrine disorders. Steroid quantification is essential to improve the understanding and diagnosis of these pathologies. Historically, urinary steroid profiling has been performed using low‐throughput gas chromatography mass ...
Joshua T. Bain   +4 more
wiley   +1 more source

The Relationships of Season, Climate, Habitat, and Sex Variables With Fecal Cortisol, Progesterone, and Testosterone Metabolite Concentrations in Roe Deer

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
Roe deer in Kiasar National Park and Wildlife Refuge, Iran; Photo by Hamed Tizrooyan. This study examined how seasonal, climatic, topographic, habitat, and sex variables influence fecal cortisol, testosterone, and progesterone metabolite concentrations in roe deer populations within Iran's Kiasar National Park and Wildlife Refuge through fecal sample ...
Seyed Mehdi Amininasab   +2 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong   +5 more
wiley   +1 more source

MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Andrea D. Re Cecconi   +11 more
wiley   +1 more source

Liver X Receptor α (LXRα) Regulates 5β‐Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 5, Page 456-461, June 2026.
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Ryan T. Paitz   +4 more
wiley   +1 more source

Nanoencapsulation of Essential Oils: A Review of Current Trends and Advances in Preparation, Characterization, and Biomedical Applications

open access: yesNano Select, Volume 7, Issue 6, June 2026.
This review highlights nanoencapsulation as a powerful strategy to improve the stability, solubility, and bioavailability of essential oils. It surveys key EO‐producing plant families, major bioactive constituents, and therapeutic properties, alongside high‐ and low‐energy nanoformulation methods. Applications across pharmaceutical, cosmetic, food, and
Mateusz Guz   +3 more
wiley   +1 more source

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