Results 131 to 140 of about 139,637 (359)

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice. [PDF]

J Physiol
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Garcia SM, Tuineau MN, DeLeon XA, Detweiler ND, Tamang S, Kanagy NL, Gonzalez Bosc LV, Resta TC, Naik JS, Jernigan NL.   +9 more
europepmc   +2 more sources

Effect of a melanocortin type 2 receptor (MC2R) antagonist on the corticosterone response to hypoxia and ACTH stimulation in the neonatal rat [PDF]

, 2018
Adam J. Goldenberg, Ashley Gehrand, Emily Waples, Mack Jablonski, Brian Hoeynck, Hershel Raff   +5 more
openalex   +1 more source

Norlignans and Phenolics from Genus <i>Curculigo</i>&nbsp;Protect Corticosterone-Injured Neuroblastoma Cells SH-SY5Y by Inhibiting Endoplasmic Reticulum Stress-Mitochondria Pathway

, 2022
Ying Wang, Zhenzhen Liu, Juanru Wei, Lei Di, Sheng Wang, Tingni Wu, Ning Li   +6 more
openalex   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Behavioural Neurology, 2014
Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated ...
Zohreh Sadat Nasihatkon, Maryam Khosravi, Zahra Bourbour, Hedayat Sahraei, Mina Ranjbaran, Seyedeh Maryam Hassantash, Mohammad Sahraei, Kefayat Baghlani   +7 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling

Scientific Reports, 2017
Stress hormones, such as corticosteroids, modulate the transmission of hippocampal glutamatergic synapses and NMDA receptor (NMDAR)-dependent synaptic plasticity, favouring salient behavioural responses to the environment.
Lenka Mikasova, Hui Xiong, Amber Kerkhofs, Delphine Bouchet, Harm J. Krugers, Laurent Groc   +5 more
doaj   +1 more source

The Effect of Background Colour on Behaviour and Development of Golden Mantella (Mantella aurantiaca) Tadpoles

Ethology, EarlyView.
This study examined how background colour influences behaviour and development in golden mantella (Mantella aurantiaca) tadpoles across ontogeny. Tadpoles preferred darker backgrounds, and this preference got less strong with increasing age. Individuals reared in darker conditions were less active but did not differ in growth rate and shelter use when ...
Prathik Amin, Joachim G. Frommen, Jade Newton‐Youens   +2 more
wiley   +1 more source

Gypenosides Attenuates CORT-Induced Ferroptosis via Inhibiting TNF-α/NF-κB Signaling Pathway in PC12 Cells

Molecules
Chronic stress can lead to nervous system dysfunction and depression-like behaviors in animals. Gypenosides can improve chronic stress-induced neuronal damage, but the protective mechanism remains poorly understood.
Lingling Dai, Jinghui Peng, Manyu Zhang, Yulin Hu, Zhicheng Gao, Jibin Wang, Haiyang Zhang, Shoujun Li   +7 more
doaj   +1 more source