Results 41 to 50 of about 69,134 (261)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Stachyose Alleviates Corticosterone-Induced Long-Term Potentiation Impairment via the Gut–Brain Axis

Frontiers in Pharmacology, 2022
Stress can induce learning and memory impairment; corticosterone is often used to study the effects and mechanisms of stress in animal models. Long-term potentiation (LTP) has been widely used for tackling the mechanisms of memory.
Yan Huang, Dong Li, Chen Wang, Na Sun, Wen-Xia Zhou   +4 more
doaj   +1 more source

THE ROLE OF ADRENAL CORTICOSTERONE IN SCHEDULE-INDUCED WHEEL RUNNING

, 1988
In 3 experiments, the role of adrenal corticosterone in schedule-induced wheel running was investigated. Data from the first experiment showed that bilateral adrenalectomy significantly suppressed schedule-induced wheel running, but did not influence ...
SINGER, G, George Singer, PAPASAVA, M, LIN, W   +3 more
core   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Stress and neurochemical changes associated with chronic alcohol administration [PDF]

, 2001
: There is considerable recent experimental evidence that suggests that stress plays a major role in the development of dependence on drugs of abuse, but the potential mechanisms involved are not yet fully understood.
O'Callaghan, Matthew Joseph
core  

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3)

Stress
Previous studies have shown that corticosterone rapidly alters extracellular serotonin (5-hydroxytryptamine; 5-HT) concentrations in the dorsomedial hypothalamus (DMH) of adult male rats, suggesting a role for corticosterone actions in the DMH in ...
Jamie L. Scholl, Joshua T. Rogers, Na Feng, Gina L. Forster, Michael J. Watt, Jazmine D. W. Yaeger, Michael W. Buchanan, Christopher A. Lowry, Kenneth J. Renner   +8 more
doaj   +1 more source

Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke

, 2017
Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well established, the specific mechanisms involved have remained largely unexplored ...
Katarzyna Zalewska, Lin Kooi Ong, Zalewska, Katarzyna, Ong, Lin Kooi, Walker, Frederick R., Nilsson, Michael, Sarah J. Johnson, Michael Nilsson, Frederick R. Walker, Johnson, Sarah J.   +9 more
core   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse [PDF]

, 2014
Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However,
Okutsu, Mitsuharu, Lira, Vitor A., Higashida, Kazuhiko, Higuchi, Mitsutoshi, Higuchi, Mitsuru, Suzuki, Katsuhiko, Peake, Jonathan   +6 more
core   +1 more source