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Corticotropin-Releasing Factor*
Endocrine Reviews, 1982IN 1948 Geoffrey Harris (1) hypothesized that stress-induced activation of the central nervous system is transduced from a neural into a humoral signal in the hypothalamus. Resultant chemical transmitter substances elaborated are transported to the adenohypophysis via the hypophyseal portal circulation to stimulate the secretion of ACTH from the ...
N, Yasuda, M A, Greer, T, Aizawa
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Corticotropin-Releasing Factor Stimulation Test
New England Journal of Medicine, 1984Abstract We investigated the effect of exogenous corticotropin-releasing factor on plasma levels of ACTH and Cortisol in 13 patients with ACTH-secreting pituitary adenomas (Cushing's disease) and in 9 patients with other forms of Cushing's syndrome. In all patients with Cushing's disease, ovine corticotropin-releasing factor, given intravenously as a ...
A N, Elias, G, Gwinup
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Corticotropin-Releasing Factors
1989Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion was proposed in 1948 (1) and confirmed in 1955 by the demonstration that a crude extract of the stalk median eminence induced ACTH secretion in the rat (2,3). The putative neurotransmitter was named corticotrophin-releasing factor, or CRF. Attempts to isolate a single CRF
Lynnette K. Nieman +2 more
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Placental Corticotropin‐Releasing Factor An Update
Annals of the New York Academy of Sciences, 2000Abstract: Corticotropin‐releasing factor (CRF) produced in placenta has paracrine effects within placenta, decidua, and myometrium and endocrine effects on mother and fetus. CRF is a potent local regulator of myometrial contractility and of prostaglandin release, Recently, urocortin, a new member of the CRF family, has been localized in human placenta
FADALTI M +7 more
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Corticotropin-releasing factor receptor antagonists
Expert Opinion on Therapeutic Patents, 2006Corticotropin-releasing factor (CRF) coordinates the neural, endocrine and immune responses of the body to stress. Therefore, CRF receptors are important targets for the design of drugs for depression, anxiety and stress-related disorders. Several laboratories have published extensive preclinical and limited clinical research into the role of CRF in ...
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[Corticotropin releasing factor].
Presse medicale (Paris, France : 1983), 1985The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor (CRF). This factor, located mainly in a paraventricular-infundibular hypothalamic tract, stimulates ACTH synthesis and secretion through a cAMP-dependent mechanism.
B, Conte-Devolx +7 more
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Corticotropin releasing factor receptors
2002Abstract Throughout life, organisms experience myriad environmental and internal perturbations perceived as ‘stressors’. The diverse strategies used in response to particular stressors are viewed as successful when they restore homeostasis and unsuccessful when they fail to do so and culminate in a disease state.
Marilyn H Perrin, Wylie W Vale
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Corticotropin-Releasing Factor Antagonists
CNS Drugs, 1999Since its isolation and characterisation in 1981, corticotropin-releasing factor (CRF) has been found to integrate not only the endocrine, but also the autonomic, immunological and behavioural, responses of mammalian organisms to stress. Direct CNS administration of CRF to laboratory animals produces actions similar to those observed after exposure to ...
Michael J. Owens, Charles B. Nemeroff
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