Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH). [PDF]
Islam MR +6 more
europepmc +1 more source
Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors. [PDF]
Maita I +11 more
europepmc +1 more source
Corticotropin-Releasing Factor Release From a Unique Subpopulation of Accumbal Neurons Constrains Action-Outcome Acquisition in Reward Learning. [PDF]
Eckenwiler EA +11 more
europepmc +1 more source
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Corticotropin-Releasing Factor*
Endocrine Reviews, 1982IN 1948 Geoffrey Harris (1) hypothesized that stress-induced activation of the central nervous system is transduced from a neural into a humoral signal in the hypothalamus. Resultant chemical transmitter substances elaborated are transported to the adenohypophysis via the hypophyseal portal circulation to stimulate the secretion of ACTH from the ...
N, Yasuda, M A, Greer, T, Aizawa
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Placental Corticotropin‐Releasing Factor An Update
Annals of the New York Academy of Sciences, 2000Abstract: Corticotropin‐releasing factor (CRF) produced in placenta has paracrine effects within placenta, decidua, and myometrium and endocrine effects on mother and fetus. CRF is a potent local regulator of myometrial contractility and of prostaglandin release, Recently, urocortin, a new member of the CRF family, has been localized in human placenta
FADALTI M +7 more
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Corticotropin‐releasing Factor in the Adrenal Medulla
Annals of the New York Academy of Sciences, 1987Immunoreactive and bioactive corticotropin-releasing factor has been identified in the adrenal gland of dogs, rats and humans. Radioimmunoassay and immunohistochemical experiments have clearly demonstrated that localization of the peptide is confined to the adrenal medulla.
T O, Bruhn +4 more
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Corticotropin-releasing factor receptors: An overview
Experimental and Clinical Endocrinology & Diabetes, 2009Corticotropin-releasing factor (CRF) is the primary physiological regulator of basal and stress-induced release of ACTH, beta-endorphin and other POMC-derived peptides from the pituitary and plays a major role in the brain and periphery in coordinating endocrine, electrophysiological, autonomic, behavioral and immune responses to stress.
K D, Dieterich +2 more
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The Status of the Corticotropin Releasing Factor (CRF)
Neuroendocrinology, 2008Early in the history of studies on the release of ACTH by stress there were indications that ACTH might be released by multiple factors. But the neurohumoral theory, as formulated by G. W. Harris, suggested that every hypophysial hormone had its unique hypothalamic controlling agent and a search for the unique ACTH-releasing hormone went on for about ...
M, Saffran, A V, Schally
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