Results 171 to 180 of about 29,028 (227)
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Corticotropin-Releasing Factor Stimulation Test
New England Journal of Medicine, 1984Abstract We investigated the effect of exogenous corticotropin-releasing factor on plasma levels of ACTH and Cortisol in 13 patients with ACTH-secreting pituitary adenomas (Cushing's disease) and in 9 patients with other forms of Cushing's syndrome. In all patients with Cushing's disease, ovine corticotropin-releasing factor, given intravenously as a ...
A N, Elias, G, Gwinup
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Corticotropin-Releasing Factors
1989Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion was proposed in 1948 (1) and confirmed in 1955 by the demonstration that a crude extract of the stalk median eminence induced ACTH secretion in the rat (2,3). The putative neurotransmitter was named corticotrophin-releasing factor, or CRF. Attempts to isolate a single CRF
Lynnette K. Nieman +2 more
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Circulating Corticotropin-Releasing Factor in Pregnancy
1990Normal circulating levels of human corticotropin releasing factor (hCRF), the most potent of the hypothalamic peptides stimulating pituitary ACTH release (1) are low, most workers reporting levels substantially below 100 pg/ml (2–10). This plasma CRF is thought to originate not only from the hypothalamus but also from several tissues outside of the ...
E A, Linton +3 more
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Desensitization of corticotropin-releasing factor receptors
Biochemical and Biophysical Research Communications, 1983Pretreatment of rat anterior pituitary cells with corticotropin releasing factor (CRF) rapidly and markedly reduced the ability of CRF to restimulate cyclic AMP formation and adrenocorticotropic hormone (ACTH) release. The effect was dependent on the length of time of pretreatment as well as the concentration of CRF.
T, Reisine, A, Hoffman
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Corticotropin-releasing factor, norepinephrine, and stress
Biological Psychiatry, 1999Corticotropin-releasing factor (CRF) and related peptides in the central nervous system appears to have activating properties on behavior and to enhance behavioral responses to stressors. CRF and urocortin injected into the brain produces increases in arousal as measured by locomotor activation and increased responsiveness to stressful stimuli.
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Antagonists of the Corticotropin Releasing Factor Receptor
2003Publisher Summary The current understanding of the corticotropin releasing factor (CRF) system implicates two distinct receptors—potentially multiple endogenous ligands and a binding protein—although the superficial view hides more subtle complexities.
John, Saunders, John, Williams
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[Corticotropin releasing factor].
Presse medicale (Paris, France : 1983), 1985The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor (CRF). This factor, located mainly in a paraventricular-infundibular hypothalamic tract, stimulates ACTH synthesis and secretion through a cAMP-dependent mechanism.
B, Conte-Devolx +7 more
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Corticotropin-releasing factor and intraocular pressure
Current Eye Research, 1985The effect of centrally administered corticotropin-releasing factor (CRF) on intraocular pressure (IOP) was investigated using the technique of ventriculocisternal perfusion. Various amounts of ovine CRF (0.01, 0.033, 0.1 and 0.33 micrograms/min) were perfused in conscious, male New Zealand albino rabbits for 1 hour.
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Corticotropin-Releasing Factor: Pharmacokinetics in Man
The Journal of Clinical Endocrinology & Metabolism, 1984Corticotropin-releasing factor (CRF), a 41-amino acid peptide isolated and sequenced from ovine hypothalami, has potential clinical application as a provocative test of the hypothalamic-pituitary-adrenal axis. To define its pharmacokinetic parameters in man, we measured the MCR and plasma half-life of immunoreactive CRF (IR-CRF) by the pulse injection ...
H M, Schulte +6 more
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