Results 181 to 190 of about 515,964 (279)

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

open access: yesMedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei   +7 more
wiley   +1 more source

Hypothalamic Corticotropin-Releasing Hormone Contributes to Hypertension in Spontaneously Hypertensive Rats. [PDF]

open access: yesJ Neurosci, 2023
Zhang H   +10 more
europepmc   +1 more source

Effects of Mindfulness Therapy on Stress Biomarkers and Psychological Symptoms in Women With Recurrent Pregnancy Loss: A Randomized Clinical Trial

open access: yesStress and Health, Volume 42, Issue 5, October 2026.
ABSTRACT Women with recurrent pregnancy loss (RPL) exhibit high levels of depression, anxiety, and stress, which negatively impact their quality of life. This randomized clinical trial evaluated the effects of an eight‐week online Mindfulness‐Based Intervention (MBI), with weekly one‐hour sessions, on psychological and biological markers of stress in ...
Elaine C. F. Oliveira   +3 more
wiley   +1 more source

Selective and Fast Cortisol Sensing in Human Saliva Using Graphene‐Based On‐Chip Field‐Effect Transistors

open access: yesSmall Science, Volume 6, Issue 10, October 2026.
Electrolyte‐gated graphene field‐effect transistors (EG‐GFETs) functionalized with anticortisol Fab fragments enable rapid, label‐free detection of cortisol in human saliva within 10 min. Sensitive operation in physiologically relevant media, together with direct validation against ELISA, demonstrates the potential of this platform for future portable ...
Bajramshahe Shkodra   +11 more
wiley   +1 more source

ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension. [PDF]

open access: yesFront Neurosci, 2023
Oliveira AC   +8 more
europepmc   +1 more source

Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease

open access: yesActa Crystallographica Section D, Volume 82, Issue 10, Page 1181-1194, October 2026.
To facilitate structure‐based drug development, XFEL sources are of paramount interest. Here, we analyse the feasibility and data quality of serial femtosecond X‐ray crystallography compound screening at Linac Coherent Light Source and compare it with PETRA III synchrotron experiments.
Sven Falke   +15 more
wiley   +1 more source

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