Results 111 to 120 of about 215,874 (309)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Salivary cortisol, job stress, and periodontal disease in nursing staff [PDF]

Revista de Odontologia da UNESP
Introduction Cortisol is recognized as a biomarker of stress, playing a crucial role in the regulation of various physiological systems. However, when released chronically, it can adversely affect periodontal tissues by diminishing their immune response,
Alessandra Arthuso ALVES, Arthur Maciel ARAUJO, Rebeca Ferreira BADARÓ, Maiara Campos Linhares SAMPAIO, Julia Saraiva de Almeida BARBOSA, Umberto Demoner RAMOS, Elizabeth Pimentel ROSETTI   +6 more
doaj   +1 more source

The Role of Awakening Cortisol and Psychological Distress in Diurnal Variations in Affect: A Day Reconstruction Study [PDF]

People often feel unhappy in the morning but better later in the day, and this pattern may be amplified in the distressed. Past work suggests that one function of cortisol is to energize people in the mornings. In a study of 174 students we tested to see
Peter P. Doran, Malcolm MacLachlan, Michael Daly, Liam Delaney   +3 more
core  

Exploring the Relationship between Childhood Interpersonal Violence, Cortisol Stress Response, and Stress Eating [PDF]

, 2013
Histories of childhood interpersonal violence have been linked to overweight and obesity in adulthood. Despite the fact that victimization experiences are likely to co-occur within individuals, few studies have examined poly-victimization in the context ...
Midei, Aimee J
core  

Mental health and salivary cortisol

, 2012
The aim of this chapter was to analyze associations between measures of cortisol in saliva and mental health and to see if divergent results were functions of the methods used.
Jonsdottír, Ingibjörg H., Halford, Christina,, Eek, Frida   +2 more
core   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Glycosylated haemoglobin (HbA1c) and cortisol levels on admission to intensive care as predictors of outcome [PDF]

, 2009
Objective: To evaluate the predictive value of glycosylated haemoglobin and cortisol on admission, in critical care patients. Design: Prospective, observational, single centre study. Setting: 14 bedded Intensive care unit of a tertiary-level university
LaFerla, Godfrey, Sant, Federika, Farrugia, Daniel P., Abela, Carmel J., Zarb Adami, Joseph, Sciberras, Stephen C.   +5 more
core  

Sleep and Salivary Cortisol

, 2011
The aim of the present chapter was to analyze whether measures of cortisol in saliva were associated with measures of sleep and to explore if divergent results were related to underlying differences in theoretic assumptions and methods. Measures of sleep
Garde, Anne Helene, Karlsson, Berndt, Hansen, Åse Marie, Karlson, Berndt, Karlsson, Berndt,, Åkerstedt, Torbjörn, Åkerstedt, Torbjörn,, Bentham Science Publisher Bentham Science Publisher, Persson, Roger, Karlson, Bernt   +9 more
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source