Results 31 to 40 of about 148,911 (237)

Comparison of salivary and serum cortisol levels in mechanically ventilated patients and non-critically ill patients [PDF]

Acute and Critical Care, 2020
Background Although the measuring free cortisol is ideal for assessment of hypothalamic-pituitary-adrenal function, it is not routinely measured. Salivary cortisol correlates well with the biologically active free cortisol. Therefore, this study measured
Jung Hee Kim, Yoon Ji Kim, Sang-Min Lee, Jinwoo Lee   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva

Pharmacology Research & Perspectives, 2020
This research was planned to build a Pharmacokinetic/Pharmacodynamic (PK/PD) model of 5‐hydroxytryptophan (5‐HTP) challenge study including a circadian rhythm component of cortisol and to predict serum cortisol based on saliva cortisol. Data from three 5‐
Zheng Guan, Gabriel Jacobs, Hans vanPelt, Joop M.A. Van Gerven, Jacobus Burggraaf, Wei Zhao   +5 more
doaj   +1 more source

Low Urinary Free Cortisol as a Risk Factor for Patients with Variceal Bleeding

Medicina, 2023
Background and Objectives: Specificity and reliability issues of the current cortisol assessment methods lead to limitations on the accurate assessment of relative adrenal insufficiency.
Ioanna Aggeletopoulou, Efthymios P. Tsounis, Maria Kalafateli, Maria Michailidou, Maria Tsami, Konstantinos Zisimopoulos, Martha Mandellou, Georgia Diamantopoulou, Maria Kouskoura, Marina Michalaki, Catherine K. Markopoulou, Konstantinos Thomopoulos, Christos Triantos   +12 more
doaj   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Time-course changes in fingernail cortisol levels during pregnancy and postpartum

Scientific Reports
The cortisol level in fingernails can reflect the cumulative hormones produced in the body several months prior. However, previous studies have only demonstrated the cross-sectional associations of fingernail cortisol with salivary or hair cortisol, and ...
Shuhei Izawa, Mikiko Kawasaki, Nagisa Sugaya, Shusaku Nomura   +3 more
doaj   +1 more source

Daily Fluctuation of Cortisol in the Saliva and Serum of Healthy Persons

Biomolecules & Biomedicine, 2008
The objective of this study was to evaluate cortisol in the saliva and serum of healthy persons and its daily fluctuations by using immunochemical method on a autoanalyzer.
Nevzeta Ljubijankić, Ranka Popović-Javorić, Sabiha Šćeta, Aida Šapčanin, Ismet Tahirović, Emin Sofić   +5 more
doaj   +1 more source

Sex differences in the association between internalizing symptoms and hair cortisol level among 10-12 year-old adolescents in China. [PDF]

PLoS ONE, 2018
Although numerous studies have described the relationship between HPA axis dysregulation and internalizing symptoms among adolescents, research using hair cortisol concentrations in pre- and young adolescent samples has not been reported. We investigated
Qingyun Lu, Fada Pan, Lingling Ren, Jing Xiao, Fangbiao Tao   +4 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Effects of gender-affirming hormones on diurnal cortisol concentrations: A prospective study

Neurobiology of Stress
The diurnal rhythm of the hypothalamic-pituitary-adrenal (HPA) axis is essential for physical and mental health. There are sex differences in this diurnal rhythm, including steeper diurnal cortisol slopes in females compared to males, and sex hormones ...
Margot W.L. Morssinkhof, David Matthew Doyle, Ysbrand D. van der Werf, Martin den Heijer, Annemieke Heijboer, Birit F.P. Broekman, Dirk Jan Stenvers   +6 more
doaj   +1 more source